Open AccessJournal Article
How to measure baroreflex sensitivity
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TLDR
The use of vasoactive drugs and the analysis of spontaneously occurring changes in blood pressure and heart rate are described.Abstract:
In normal subjects arterial baroreflexes play a key role in short-term blood pressure adjustments to a variety of environmental stresses, thereby maintaining circulatory homeostasis. These responses are mediated by the sympathetic and parasympathetic nervous systems through their effects on heart rate, venous return, contractility and peripheral resistance. The evaluation of baroreflex sensitivity (BRS) has recently found unexpected exploitations as alterations in the baroreflex control of heart rate have been associated with an increased propensity for cardiac mortality and sudden cardiac death [1]. Among several quantitative approaches developed for evaluating BRS including the analysis of reflex responses to pharmacological or mechanical manipulations of baroreceptors, this article describes the use of vasoactive drugs and the analysis of spontaneously occurring changes in blood pressure and heart rate.read more
Citations
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Journal ArticleDOI
Applicability and clinical relevance of the transfer function method in the assessment of baroreflex sensitivity in heart failure patients.
Gian Domenico Pinna,Roberto Maestri,Soccorso Capomolla,Oreste Febo,Elena Robbi,Franco Cobelli,Maria Teresa La Rovere +6 more
TL;DR: In CHF patients in sinus rhythm, TF-BRS conveys relevant clinical and prognostic information, but its measurability is markedly affected by ectopic activity, and a new prognostic index can be computed in almost all patients.
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Baroreflex mechanisms in major depression
TL;DR: The data indicate that different baroreflex components and mechanisms may be impaired in patients with depression and may contribute to their increased cardiac risk.
Journal ArticleDOI
Restoration of baroreflex function in patients with end-stage renal disease after renal transplantation
TL;DR: The data show that renal transplantation improves blood pressure and HRV and restores baroreflex function to near normal range on the long-term follow-up and these effects may contribute to the improvement of blood pressure control and survival after successful transplantation.
Journal ArticleDOI
The repeated sit-to-stand maneuver is a superior method for cardiac baroreflex assessment: a comparison with the modified Oxford method and Valsalva maneuver
TL;DR: Findings indicate the sit-to-stand method is a statistically reliable BRS assessment tool and suitable for the examination of baroreflex hysteresis.
Journal ArticleDOI
Why is blood pressure so hard to control in patients with type 2 diabetes
TL;DR: The authors focus on the mechanisms of resistance to antihypertensive therapy (particularly for monotherapy with either angiotensin-converting enzyme inhibitors or angiotENSin II antagonists) in the treatment of diabetic hypertension.
References
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Journal ArticleDOI
Early alterations of the baroreceptor control of heart rate in patients with acute myocardial infarction.
Giuseppe Osculati,Guido Grassi,Cristina Giannattasio,Gino Seravalle,Franco Valagussa,Alberto Zanchetti,G. Mancia +6 more
TL;DR: MI is accompanied by an acute marked impairment of the baroreceptor control of the heart in humans, and this is the case both for an anterior and an inferior MI.
Journal ArticleDOI
Measuring baroreflex sensitivity from the gain function between arterial pressure and heart period.
TL;DR: The WBA-BRS method standardizes the computation of BRS among subjects, and dramatically increases its measurability in subjects with pathology compared with the classical spectral technique based on the coherence criterion.
Journal ArticleDOI
Applicability and clinical relevance of the transfer function method in the assessment of baroreflex sensitivity in heart failure patients.
Gian Domenico Pinna,Roberto Maestri,Soccorso Capomolla,Oreste Febo,Elena Robbi,Franco Cobelli,Maria Teresa La Rovere +6 more
TL;DR: In CHF patients in sinus rhythm, TF-BRS conveys relevant clinical and prognostic information, but its measurability is markedly affected by ectopic activity, and a new prognostic index can be computed in almost all patients.
Journal ArticleDOI
Assessing Baroreflex Sensitivity in Post-Myocardial Infarction Patients: Comparison of Spectral and Phenylephrine Techniques
TL;DR: Despite a substantial linear association, the agreement between spectral measurements and Phe-BRS in post-myocardial infarction patients is weak because the difference can be as large as the BRS value being estimated.
Journal ArticleDOI
Comparison between invasive and non-invasive measurements of baroreflex sensitivity; implications for studies on risk stratification after a myocardial infarction.
TL;DR: Despite wide limits of agreement, invasive and non-invasive baroreflex sensitivity measurements are highly correlated and provide equivalent prognostic information.