HSP90 at the hub of protein homeostasis: emerging mechanistic insights
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...…in prokaryotes to the most sophisticated chaperone machinery known in eukaryotes, working together with a large cohort of cochaperones that associate in a defined order during the chaperone cycle (Figure 3) (Pearl and Prodromou, 2006; Taipale et al., 2010; Wandinger et al., 2008; Li et al., 2010)....
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...Third, it appears to have evolved from a single component system in prokaryotes to the most sophisticated chaperone machinery known in eukaryotes, working together with a large cohort of cochaperones that associate in a defined order during the chaperone cycle (Figure 3) (Pearl and Prodromou, 2006; Taipale et al., 2010; Wandinger et al., 2008; Li et al., 2010)....
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