Human D-Amino Acid Oxidase: Structure, Function, and Regulation
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Cites background from "Human D-Amino Acid Oxidase: Structu..."
...Here, D-serine cellular concentration is modulated by the catabolic activity of DAAO [27, 28]....
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...Here, D-serine cellular concentration is modulated by the catabolic activity of DAAO [27, 28]....
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...1 3 Taken together, elucidating the mechanisms affecting the function of enzymes belonging to the phosphorylated pathway and those related to serine metabolism (namely, SR, DAAO, and SHMT) might provide key information for designing specific molecular approaches/tools by which cellular concentrations of serine could be finely tuned....
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...D-Serine is then degraded by both the α and β-elimination reaction catalyzed by SR and oxidative deamination catalyzed by d-amino acid oxidase (DAAO, EC 1.4.3.3) [25–28] (Fig....
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24 citations
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Cites background from "Human D-Amino Acid Oxidase: Structu..."
...Here, DAO catalyzes D- November 2020 | Volume 10 | Article 586923 cysteine to 3-mercaptopyruvate, the substrate for 3-MST (Figure 1) (Shibuya et al., 2013; Pollegioni et al., 2018)....
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...3-MP is also generated from D-cysteine by D-amino acid oxidase (DAO) (Shibuya et al., 2013; Pollegioni et al., 2018)....
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17 citations
References
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"Human D-Amino Acid Oxidase: Structu..." refers background in this paper
...An NMDAR hypofunction was also related to schizophrenia (Coyle et al., 2003; Coyle, 2006; Stone and Pilowsky, 2007): the altered activation state of the receptor was proposed to depend on a deficiency in D-serine signaling (Hashimoto et al....
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...An NMDAR hypofunction was also related to schizophrenia (Coyle et al., 2003; Coyle, 2006; Stone and Pilowsky, 2007): the altered activation state of the receptor was proposed to depend on a deficiency in D-serine signaling (Hashimoto et al., 2003, 2005; Verrall et al., 2010)....
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871 citations
"Human D-Amino Acid Oxidase: Structu..." refers background in this paper
...More than 500 substrate-competitive inhibitors have been identified so far (Gilson et al., 2016)....
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813 citations
"Human D-Amino Acid Oxidase: Structu..." refers background in this paper
...A recent, comprehensive, exomesequencing study revealed that the only DNA variants associated with clinical outcome of ALS and with lower rates of survival are located on the DAO gene (Cirulli et al., 2015)....
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802 citations
"Human D-Amino Acid Oxidase: Structu..." refers background in this paper
...Further support comes from the discovery that the G72 gene, encoding the small protein pLG72, the main hDAAO-specific binding protein (see below), has been linked to schizophrenia (Chumakov et al., 2002; Sacchi et al., 2008, 2016; Pollegioni et al., 2018)....
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