Journal ArticleDOI
Human FoxP3+ regulatory T cells in systemic autoimmune diseases
Makoto Miyara,Guy Gorochov,Michael R. Ehrenstein,Lucile Musset,Shimon Sakaguchi,Shimon Sakaguchi,Zahir Amoura +6 more
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TLDR
Since the characterization of CD4(+)CD25(+) regulatory T (Treg) cells in mice, significant progress has been made in the definitions of the phenotype and the function of human Treg cells in health and in pathological conditions.About:
This article is published in Autoimmunity Reviews.The article was published on 2011-10-01. It has received 307 citations till now. The article focuses on the topics: FOXP3 & IL-2 receptor.read more
Citations
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Journal ArticleDOI
Regulatory T cells in autoimmune disease.
TL;DR: How the instability and plasticity of Treg cells can contribute to the breakdown of tolerance and lead to autoimmune disease is described.
Journal ArticleDOI
Human FOXP3+ Regulatory T Cell Heterogeneity and Function in Autoimmunity and Cancer
TL;DR: Findings within the context of concepts in Treg cell development and function derived from preclinical models and insight from approaches targeting Treg cells in clinical settings are discussed.
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From IL-2 to IL-37: the expanding spectrum of anti-inflammatory cytokines
TL;DR: Some of the regulatory cytokines that have evolved to permit tolerance to components of self as well as the eradication of pathogens with minimal collateral damage to the host are discussed.
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A molecular basis for the association of the HLA-DRB1 locus, citrullination, and rheumatoid arthritis
S.W. Scally,Jan Petersen,Soi Cheng Law,Nadine L. Dudek,Hendrik J. Nel,Khai Lee Loh,Lakshmi C. Wijeyewickrema,Sidonia B G Eckle,Jurgen van Heemst,Robert N. Pike,James McCluskey,René E. M. Toes,Nicole L. La Gruta,Anthony W. Purcell,Hugh H. Reid,Ranjeny Thomas,Jamie Rossjohn,Jamie Rossjohn +17 more
TL;DR: A comprehensive structural portrait of the association between citrullination, the HLA-DRB1 locus, and T cell autoreactivity in rheumatoid arthritis is presented.
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The X chromosome and immune associated genes
TL;DR: X chromosome might well constitute the common trait of the susceptibility to autoimmune diseases, other than to explain the female preponderance of these conditions, and the available evidence on X chromosome changes are focused on.
References
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Journal ArticleDOI
Control of Regulatory T Cell Development by the Transcription Factor Foxp3
TL;DR: Foxp3, which encodes a transcription factor that is genetically defective in an autoimmune and inflammatory syndrome in humans and mice, is specifically expressed in naturally arising CD4+ regulatory T cells and retroviral gene transfer of Foxp3 converts naïve T cells toward a regulatory T cell phenotype similar to that of naturally occurring CD4+.
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Foxp3 programs the development and function of CD4 + CD25 + regulatory T cells
TL;DR: It is reported that the forkhead transcription factor Foxp3 is specifically expressed in CD4+CD25+ regulatory T cells and is required for their development and function and ectopic expression ofFoxp3 confers suppressor function on peripheral CD4-CD25− T cells.
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Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells.
Estelle Bettelli,Yijun Carrier,Wenda Gao,Thomas Korn,Terry B. Strom,Mohamed Oukka,Howard L. Weiner,Vijay K. Kuchroo +7 more
TL;DR: It is shown that IL-6, an acute phase protein induced during inflammation, completely inhibits the generation of Foxp3+ Treg cells induced by TGF-β, and the data demonstrate a dichotomy in thegeneration of pathogenic (TH17) T cells that induce autoimmunity and regulatory (Foxp3+) T Cells that inhibit autoimmune tissue injury.
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Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases.
TL;DR: The authors showed that CD4+CD25+ cells contribute to maintaining self-tolerance by downregulating immune response to self and non-self Ags in an Ag-nonspecific manner, presumably at the T cell activation stage.
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Interleukin 17–producing CD4 + effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages
Laurie E. Harrington,Robin D. Hatton,Paul R. Mangan,Henrietta Turner,Theresa L. Murphy,Kenneth M. Murphy,Casey T. Weaver +6 more
TL;DR: Findings provide a basis for understanding how inhibition of IFN-γ signaling enhances development of pathogenic TH-17 effector cells that can exacerbate autoimmunity.