Human mesenchymal stem cell-conditioned medium improves cardiac function following myocardial infarction
Leo Timmers,Sai Kiang Lim,Imo E. Hoefer,Fatih Arslan,Ruenn Chai Lai,Angelique A M Van Oorschot,Marie-José Goumans,Chaylendra Strijder,Sui Kwan Sze,Andree Choo,Jan J. Piek,Pieter A. Doevendans,Gerard Pasterkamp,Dominique P.V. de Kleijn +13 more
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TLDR
Intravenous MSC-CM treatment after myocardial infarction increases capillary density and preserves cardiac function, probably by increasing myocardia perfusion.About:
This article is published in Stem Cell Research.The article was published on 2011-05-01 and is currently open access. It has received 373 citations till now. The article focuses on the topics: Myocardial infarction & Transplantation.read more
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Extracellular vesicles: biology and emerging therapeutic opportunities
TL;DR: Recent progress in understanding extracellular vesicle biology and the role of extrace cellular vesicles in disease is reviewed, emerging therapeutic opportunities are discussed and the associated challenges are considered.
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Extracellular vesicle in vivo biodistribution is determined by cell source, route of administration and targeting
Oscar P. B. Wiklander,Joel Z. Nordin,Aisling J. O’Loughlin,Ylva Gustafsson,Giulia Corso,Imre Mäger,Pieter Vader,Yi Lee,Helena Sork,Yiqi Seow,Nina Heldring,Lydia Alvarez-Erviti,C. I. Edvard Smith,Katarina Le Blanc,Paolo Macchiarini,Philipp Jungebluth,Matthew J.A. Wood,Samir El Andaloussi +17 more
TL;DR: This is the first extensive biodistribution investigation of EVs comparing the impact of several different variables, the results of which have implications for the design and feasibility of therapeutic studies using EVs.
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Mesenchymal Stem Cell Secretome: Toward Cell-Free Therapeutic Strategies in Regenerative Medicine
TL;DR: Among MSCs, human uterine cervical stem cells (hUCESCs) may be a good candidate for obtaining secretome-derived products, and regulatory requirements for manufacturing and quality control will be necessary to establish the safety and efficacy profile of these products.
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Harnessing the mesenchymal stem cell secretome for the treatment of cardiovascular disease.
Sudhir H. Ranganath,Oren Levy,Oren Levy,Oren Levy,Maneesha S. Inamdar,Maneesha S. Inamdar,Jeffrey M. Karp,Jeffrey M. Karp,Jeffrey M. Karp +8 more
TL;DR: The current understanding of the MSC secretome as a therapeutic for treatment of ischemic heart disease is outlined and ongoing investigative directions aimed at improving cellular activity and characterizing the secretome and its regulation are discussed.
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Mesenchymal stem cell: An efficient mass producer of exosomes for drug delivery☆
TL;DR: Of the cell types known to produce exosomes, the readily available proliferative, immunosuppressive and clinically tested human mesenchymal stem cell (MSC) is the most prolific producer.
References
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Journal ArticleDOI
Mesenchymal stem cells as trophic mediators.
Arnold I. Caplan,James E. Dennis +1 more
TL;DR: Several studies which tested the use of MSCs in models of infarct (injured heart), stroke (brain), or meniscus regeneration models are reviewed within the context of M SC‐mediated trophic effects in tissue repair.
Journal ArticleDOI
Repair of Infarcted Myocardium by Autologous Intracoronary Mononuclear Bone Marrow Cell Transplantation in Humans
Bodo E. Strauer,Michael A. Brehm,Tobias Zeus,Matthias Köstering,Anna Hernandez,Rüdiger V. Sorg,Gesine Kögler,Peter Wernet +7 more
TL;DR: Ten patients who were treated by intracoronary transplantation of autologous, mononuclear bone marrow cells (BMCs) in addition to standard therapy after MI found that the infarct region had decreased significantly within the cell therapy group and was also significantly smaller compared with the standard therapy group.
Journal ArticleDOI
Intracoronary bone marrow-derived progenitor cells in acute myocardial infarction.
Volker Schächinger,Sandra Erbs,Albrecht Elsässer,Werner Haberbosch,Rainer Hambrecht,Hans Hölschermann,Jiangtao Yu,Roberto Corti,D. G. Mathey,Christian W. Hamm,Tim Suselbeck,Birgit Assmus,Torsten Tonn,Stefanie Dimmeler,Andreas M. Zeiher +14 more
TL;DR: Intracoronary administration of BMC is associated with improved recovery of left ventricular contractile function in patients with acute myocardial infarction and large-scale studies are warranted to examine the potential effects of progenitor-cell administration on morbidity and mortality.
Journal ArticleDOI
Exosome secreted by MSC reduces myocardial ischemia/reperfusion injury.
Ruenn Chai Lai,Fatih Arslan,May May Lee,Newman Siu Kwan Sze,Andre Choo,Tiansheng Chen,Manuel Salto-Tellez,Leo Timmers,Chuen Neng Lee,Reida El Oakley,Gerard Pasterkamp,Dominique P.V. de Kleijn,Sai Kiang Lim +12 more
TL;DR: The novel role of exosomes highlights a new perspective into intercellular mediation of tissue injury and repair, and engenders novel approaches to the development of biologics for tissue repair.
Journal ArticleDOI
Paracrine action accounts for marked protection of ischemic heart by Akt-modified mesenchymal stem cells
Massimiliano Gnecchi,Massimiliano Gnecchi,Huamei He,Olin D. Liang,Luis G. Melo,Luis G. Melo,Luis G. Melo,Fulvio Morello,Fulvio Morello,Hui Mu,Hui Mu,Nicolas Noiseux,Lunan Zhang,Lunan Zhang,Richard E. Pratt,Richard E. Pratt,Joanne S. Ingwall,Victor J. Dzau,Victor J. Dzau +18 more
TL;DR: Paracrine action accounts for marked protection of ischemic heart by Akt-modified mesenchymal stem cells as discussed by the authors, which was shown to be beneficial for the preservation of the heart.