Human monocytes and macrophages differ in their mechanisms of adaptation to hypoxia
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Cites background from "Human monocytes and macrophages dif..."
...Among them the M1 macorphages which instantly switch to an anaerobic energy supply and remain active (Fangradt et al. 2012)....
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References
276 citations
"Human monocytes and macrophages dif..." refers background in this paper
...Mature monocytes migrate towards sites of inflammation and infection where they differentiate into inflammatory macrophages or into dendritic cells (DCs) [1,4,5]....
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...Monocytes and macrophages require energy in the form of adenosine triphosphate (ATP) in order to facilitate motion (migration to achieve phagocytosis), activation (signal cascade, initiation, maintenance, cytokine production) and effector functions (phagocytosis, antigen presentation, regulatory functions) [4]....
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238 citations
"Human monocytes and macrophages dif..." refers background in this paper
...In the literature, it has been reported that adaptive responses to hypoxia are regulated by several transcription factors, including HIF-1, HIF-2, ETS-1, cAMP response element binding protein, activator protein-1 and nuclear factor- B [26-33]....
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205 citations
"Human monocytes and macrophages dif..." refers background in this paper
...Hypoxia occurs in joint inflammation such as during the pathogenesis of rheumatoid arthritis [1,5], fracture hematomas [8], and malignant tumors [9]....
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...Inflammatory arthritis is characterized by infiltration of immune cells and local tissue hypoxia [1-3]....
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...Mature monocytes migrate towards sites of inflammation and infection where they differentiate into inflammatory macrophages or into dendritic cells (DCs) [1,4,5]....
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198 citations
"Human monocytes and macrophages dif..." refers background in this paper
...terisation of monocytes incubated under hypoxia [40]....
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...[40], we showed that hypoxia strengthens the genetic expression of the glycolysis enzyme LDHA....
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183 citations
"Human monocytes and macrophages dif..." refers background in this paper
...In the literature, it has been reported that adaptive responses to hypoxia are regulated by several transcription factors, including HIF-1, HIF-2, ETS-1, cAMP response element binding protein, activator protein-1 and nuclear factor- B [26-33]....
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