Human skin wounds: a major and snowballing threat to public health and the economy.
Chandan K. Sen,Gayle M. Gordillo,Sashwati Roy,Robert S. Kirsner,Lynn Lambert,Thomas K. Hunt,Finn Gottrup,Geoffrey C. Gurtner,Michael T. Longaker +8 more
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TLDR
The immense economic and social impact of wounds in the authors' society calls for allocation of a higher level of attention and resources to understand biological mechanisms underlying cutaneous wound complications.Abstract:
In the United States, chronic wounds affect 6.5 million patients. An estimated excess of US$25 billion is spent annually on treatment of chronic wounds and the burden is rapidly growing due to increasing health care costs, an aging population and a sharp rise in the incidence of diabetes and obesity worldwide. The annual wound care products market is projected to reach $15.3 billion by 2010. Chronic wounds are rarely seen in individuals who are otherwise healthy. In fact, chronic wound patients frequently suffer from "highly branded" diseases such as diabetes and obesity. This seems to have overshadowed the significance of wounds per se as a major health problem. For example, NIH's Research Portfolio Online Reporting Tool (RePORT; http://report.nih.gov/), directed at providing access to estimates of funding for various disease conditions does list several rare diseases but does not list wounds. Forty million inpatient surgical procedures were performed in the United States in 2000, followed closely by 31.5 million outpatient surgeries. The need for post-surgical wound care is sharply on the rise. Emergency wound care in an acute setting has major significance not only in a war setting but also in homeland preparedness against natural disasters as well as against terrorism attacks. An additional burden of wound healing is the problem of skin scarring, a $12 billion annual market. The immense economic and social impact of wounds in our society calls for allocation of a higher level of attention and resources to understand biological mechanisms underlying cutaneous wound complications.read more
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Wound repair and regeneration: Mechanisms, signaling, and translation
TL;DR: In this review, emerging concepts in tissue regeneration and repair are highlighted, and some perspectives on how to translate current knowledge into viable clinical approaches for treating patients with wound-healing pathologies are provided.
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Inflammation and wound healing: the role of the macrophage.
Timothy J. Koh,Luisa A. DiPietro +1 more
TL;DR: The macrophage continues to be an attractive therapeutic target, both to reduce fibrosis and scarring, and to improve healing of chronic wounds, as a result of advances in the understanding of this multifunctional cell.
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Chronic Wound Healing: A Review of Current Management and Treatments
George Han,Roger I. Ceilley +1 more
TL;DR: Wound healing physiology is reviewed and current approaches for treating a wound are discussed, showing how the healing of a superficial wound requires many factors to work in concert, and wound dressings and treatments have evolved considerably.
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Wound Healing: A Cellular Perspective.
TL;DR: It is shown that changes in the microenvironment including alterations in mechanical forces, oxygen levels, chemokines, extracellular matrix and growth factor synthesis directly impact cellular recruitment and activation, leading to impaired states of wound healing.
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Transition from inflammation to proliferation: a critical step during wound healing
TL;DR: This review summarizes mechanisms regulating the inflammation–proliferation transition at cellular and molecular levels and proposes that identification of such mechanisms will reveal promising targets for development of more effective therapies.
References
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Cutaneous Wound Healing
TL;DR: The state of knowledge regarding wound healing is described, both what is known and what is not known, and to recap the priorities set by the breakout sessions of the Burn State of the Science: Research meeting.