Journal ArticleDOI
Human stem cells as targets for the aging and diseases of aging processes.
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In this paper, the authors considered the cybernetic feedback between the number of stem cells in each tissue and the quality of the stem cells, and proposed a hypothesis that both aging and diseases of aging are dependent on the normal functioning of the pluripotent stem cell pool.About:
This article is published in Medical Hypotheses.The article was published on 2003-03-01. It has received 27 citations till now. The article focuses on the topics: Stem cell theory of aging & Stem cell.read more
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Use and application of stem cells in toxicology.
TL;DR: A review of the applications of stem cell technology in the area of toxicology can be found in this paper, where core technologies that are emerging in the field and how they could fulfill critical safety issues such as QT prolongation and hepatotoxicity, two leading causes of failures in preclinical development of new therapeutic drugs.
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Effects of aging and niche microenvironment on spermatogonial stem cell self-renewal.
TL;DR: Data suggest that infertility in old males results from deterioration of the SSC niche and failure to support an appropriate balance between stem cell self‐renewal and differentiation, which lead to system failure.
Journal ArticleDOI
Chromosome conformation capture technologies and their impact in understanding genome function
TL;DR: The evolution of 3C and other 3C-based methods for the analysis of chromatin interactions are described, along with a brief summary of their contribution in uncovering the significance of the three-dimensional world within the nucleus.
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Histone deacetylase controls adult stem cell aging by balancing the expression of polycomb genes and jumonji domain containing 3
Jiwon Jung,Seung-Hee Lee,Min-Soo Seo,Sang-Bum Park,Andreas Kurtz,Soo-Kyung Kang,Kyung-Sun Kang +6 more
TL;DR: It is suggested that HDAC activity might be important for MSC self-renewal by balancing PcGs and JMJD3 expression, which govern cellular senescence by p16INK4A regulation.
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Presence of Functional Gap Junctions in Human Embryonic Stem Cells
TL;DR: In this paper, the presence and functionality of gap junctions in human embryonic stem cells (hESCs) was determined using reverse transcription and immunocytochemistry, and two gap junction proteins were found to be expressed in human ES cells and three phosphorylated forms (nonphosphorylated [NP], P1, and P2) of connexin 43 were identified.
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Journal ArticleDOI
Aging: A Theory Based on Free Radical and Radiation Chemistry
TL;DR: It seems possible that one factor in aging may be related to deleterious side attacks of free radicals (which are normally produced in the course of cellular metabolism) on cell constituents.
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Viable offspring derived from fetal and adult mammalian cells
TL;DR: The birth of lambs from differentiated fetal and adult cells confirms that differentiation of that cell did not involve the irreversible modification of genetic material required for development to term and reinforces previous speculation that by inducing donor cells to become quiescent it will be possible to obtain normal development from a wide variety of differentiated cells.
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Oxidative Stress, Caloric Restriction, and Aging
TL;DR: Support for this hypothesis includes the following observations: (i) Overexpression of antioxidative enzymes retards the age-related accrual of oxidative damage and extends the maximum life-span of transgenic Drosophila melanogaster and (ii) Variations in longevity among different species inversely correlate with the rates of mitochondrial generation of the superoxide anion radical and hydrogen peroxide.
Book
Cancer Epidemiology and Prevention
TL;DR: This is an account of cancer epidemiology has been expanded and contains new material on cancer biology, molecular epidemiology, preventive strategies and specific types and sites of cancer.
Journal ArticleDOI
Full-term development of mice from enucleated oocytes injected with cumulus cell nuclei
Teruhiko Wakayama,Anthony C.F. Perry,Anthony C.F. Perry,Maurizio Zuccotti,Maurizio Zuccotti,K R Johnson,Ryuzo Yanagimachi +6 more
TL;DR: These experiments show that for mammals, nuclei from terminally differentiated, adult somatic cells of known phenotype introduced into enucleated oocytes are capable of supporting full development.