Humanized mice in translational biomedical research
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...immunocompromised mice of the NOD/SCID interleukin-2 receptor gamma chain null strain (NSG) (Shultz et al., 2007)....
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...In these NSG mice, high TGF-b levels were also capable of enhancing tumor initiation, although fewer cancer cells were required to form tumors in this strain (Figure S3E)....
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...Five-tosix-week-old Balb/c nude or NSG mice (Jackson Laboratories) were used to perform metastasis experiments by intrasplenic injection (Warren et al., 1995) or intracecum injection (Céspedes et al., 2007)....
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...To this end, we injected CRC cells in severely . immunocompromised mice of the NOD/SCID interleukin-2 receptor gamma chain null strain (NSG) (Shultz et al., 2007)....
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...Of note, these experiments were performed in NSG mice, which rules out that LY2157299 blocked metastasis through changes in the function of the immune system....
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"Humanized mice in translational bio..." refers methods in this paper
...This hypothesis is based on the observation that a rare fraction of cells with stem-cell properties can initiate tumour growt...
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"Humanized mice in translational bio..." refers methods in this paper
...The use of the NOD- scid strains is helping to define human tumour stem cells phenotypically and functionally, in particular the stem cells that might be responsible for AM...
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4,019 citations