Hydrogel corneal contact lenses drug carrier

TLDR: In this article, a hydrogel corneal contact lens drug carrier is presented, which is prepared by polymerization of a double bond-containing chitosan derivative, hydroxyethyl methacrylate and N-vinyl pyrrolidone in the presence of an initiator.

Abstract: The invention discloses a hydrogel corneal contact lens drug carrier, which is prepared by polymerization of a double bond-containing chitosan derivative, hydroxyethyl methacrylate and N-vinyl pyrrolidone in the presence of an initiator. Terpolymer hydrogel provided by the invention has good water absorbing swelling and transparence after polymerization, no obvious deformation, good water retention properties, high oxygen permeability value, large amount of drug loading, and stronger anti-protein adsorption ability than that of bipolymer hydrogel. The performances of the novel hydrogel corneal contact lens drug carrier with good oxygen permeability and controlled release drug capabilities meet the basic requirements of corneal contact lens, the release of eyedrops can be controlled, and the social and economic benefits are greater.