Hydrogel-forming microneedles for rapid and efficient skin deposition of controlled release tip-implants
TL;DR: In this article, a hybrid microneedle patch with implantable poly(lactic-co-glycolic acid) (PLGA) tips aligned with hydrogel-forming micronedle bases (HFMB) using a dissolvable material was introduced.
About: This article is published in Materials Science and Engineering: C.The article was published on 2021-08-01. It has received 35 citations till now. The article focuses on the topics: Antifungal drug & PLGA.
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TL;DR: Car carbohydrate-based microarrays have a high potential to achieve a future step in sensing, drug delivery, and biologics restitution, and are considered as the new class of topical drug delivery systems.
Abstract: In this focused progress review, the most widely accepted methods of transdermal drug delivery are hypodermic needles, transdermal patches and topical creams. However, microneedles (MNs) (or microneedle arrays) are low-invasive 3D biomedical constructs that bypass the skin barrier and produce systemic and localized pharmacological effects. In the past, biomaterials such as carbohydrates, due to their physicochemical properties, have been extensively used to manufacture microneedles (MNs). Due to their wide range of functional groups, carbohydrates enable the design and development of tunable properties and functionalities. In recent years, numerous microneedle products have emerged on the market, although much research needs to be undertaken to overcome the various challenges before the successful introduction of microneedles into the market. As a result, carbohydrate-based microarrays have a high potential to achieve a future step in sensing, drug delivery, and biologics restitution. In this review, a comprehensive overview of carbohydrates such as hyaluronic acid, chitin, chitosan, chondroitin sulfate, cellulose and starch is discussed systematically. It also discusses the various drug delivery strategies and mechanical properties of biomaterial-based MNs, the progress made so far in the clinical translation of carbohydrate-based MNs, and the promotional opportunities for their commercialization. In conclusion, the article summarizes the future perspectives of carbohydrate-based MNs, which are considered as the new class of topical drug delivery systems.
39 citations
TL;DR: In this article, microneedle patches (DMP) were loaded with micronized particles of AmB to achieve localised and long-acting intradermal delivery of Amb for treatment of cutaneous fungal infections.
32 citations
TL;DR: In this paper, the authors describe the development of long-acting dissolving and implantable PLGA MAPs aimed for systemic release of Finasteride for at least two weeks.
27 citations
TL;DR: In this paper , the authors presented a highly stable electrochemical biosensor based on a redox mediator bilayer consisting of Prussian blue and iron-nickel hexacyanoferrate to increase the long-term stability of the readout coupled with a hollow MN array as a sampling unit for ISF uptake.
20 citations
References
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TL;DR: Drug dissolution from solid dosage forms has been described by kinetic models in which the dissolved amount of drug (Q) is a function of the test time, t or Q=f(t).
4,794 citations
TL;DR: A major focus of this review is on factors that modulate the interaction of macrophages and foreign body giant cells on synthetic surfaces where the chemical, physical, and morphological characteristics of the synthetic surface are considered to play a role in modulating cellular events.
4,053 citations
01 Jan 2010
TL;DR: The official goal of the ICH is to harmonize inconsistent technical regulatory standards across different regions and countries in order to avoid costly, wasteful, and duplicative testing in pharmaceutical development.
Abstract: The International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use (ICH) is a combined industry and government organization. It is centrally involved in constructing and setting international technical standards for the testing, development, and monitoring of pharmaceuticals, especially in the fields of drug quality, safety, and efficacy. There are two types of memberships: full membership with voting rights; and membership that permits only 'observer' status without voting rights. The ICH Steering Committee (SC) was established in 1990 and determines the policies and procedures for ICH, selects the topics for harmonization and monitors the progress of harmonization initiatives. The core financial support for ICH is, and has been, provided by the international pharmaceutical industry trade associations. The official goal of the ICH is to harmonize inconsistent technical regulatory standards across different regions and countries in order to avoid costly, wasteful, and duplicative testing in pharmaceutical development. Keywords: drug regulatory authorities; ICH; ICH Steering Committee (SC); international pharmaceutical industry
1,137 citations
TL;DR: The development of a software program, called DDSolver, for facilitating the assessment of similarity between drug dissolution data and to establish a model library for fitting dissolution data using a nonlinear optimization method is described.
Abstract: In recent years, several mathematical models have been developed for analysis of drug dissolution data, and many different mathematical approaches have been proposed to assess the similarity between two drug dissolution profiles. However, until now, no computer program has been reported for simplifying the calculations involved in the modeling and comparison of dissolution profiles. The purposes of this article are: (1) to describe the development of a software program, called DDSolver, for facilitating the assessment of similarity between drug dissolution data; (2) to establish a model library for fitting dissolution data using a nonlinear optimization method; and (3) to provide a brief review of available approaches for comparing drug dissolution profiles. DDSolver is a freely available program which is capable of performing most existing techniques for comparing drug release data, including exploratory data analysis, univariate ANOVA, ratio test procedures, the difference factor f
1, the similarity factor f
2, the Rescigno indices, the 90% confidence interval (CI) of difference method, the multivariate statistical distance method, the model-dependent method, the bootstrap f
2 method, and Chow and Ki’s time series method. Sample runs of the program demonstrated that the results were satisfactory, and DDSolver could be served as a useful tool for dissolution data analysis.
1,045 citations
TL;DR: Microneedles are significantly less painful than a 26-gauge hypodermic needle over the range of dimensions investigated and decreasing microneedle length and number reduces pain in normal human volunteers.
Abstract: ObjectivesTo design microneedles that minimize pain, this study tested the hypothesis that microneedles cause significantly less pain than a 26-gauge hypodermic needle, and that decreasing microneedle length and the number of microneedles reduces pain in normal human volunteers.MethodsSingle microne
489 citations