Hydrogel Nanoparticles in Drug Delivery

doi:10.1016/J.ADDR.2008.08.002

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Hydrogel Nanoparticles in Drug Delivery

Journal Article•DOI•

Hydrogel Nanoparticles in Drug Delivery

Mehrdad Hamidi¹, Amir Azadi¹, Pedram Rafiei¹•Institutions (1)

Shiraz University of Medical Sciences¹

14 Dec 2008-Advanced Drug Delivery Reviews (Elsevier)-Vol. 60, Iss: 15, pp 1638-1649

TL;DR: Hydrogel nanoparticles have gained considerable attention in recent years as one of the most promising nanoparticulate drug delivery systems owing to their unique potentials via combining the characteristics of a hydrogel system with a nanoparticle, each with its own advantages and drawbacks.

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About: This article is published in Advanced Drug Delivery Reviews.The article was published on 2008-12-14. It has received 1704 citations till now. The article focuses on the topics: Nanogel & Drug carrier.

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Journal Article•DOI•

Hydrogel: Preparation, characterization, and applications: A review

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Enas M. Ahmed

01 Mar 2015-Journal of Advanced Research

TL;DR: A review of the literature concerning classification of hydrogels on different bases, physical and chemical characteristics of these products, and technical feasibility of their utilization is presented in this paper, together with technologies adopted for hydrogel production together with process design implications, block diagrams, and optimized conditions of the preparation process.

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3,529 citations

Journal Article•DOI•

Chitosan-based hydrogels for controlled, localized drug delivery

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Narayan Bhattarai¹, Jonathan Gunn¹, Miqin Zhang¹•Institutions (1)

University of Washington¹

31 Jan 2010-Advanced Drug Delivery Reviews

TL;DR: The newest developments in chitosan hydrogel preparation are investigated and the design parameters in the development of physically and chemically cross-linked hydrogels are defined.

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2,034 citations

Cites background from "Hydrogel Nanoparticles in Drug Deli..."

...Fully swollen hydrogels have some physical properties common to living tissues, including a soft and rubbery consistency, and low interfacial tension with water or biological fluids [8,14,15]....
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Journal Article•DOI•

Biomedical applications of hydrogels: A review of patents and commercial products

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Enrica Caló¹, Vitaliy V. Khutoryanskiy¹•Institutions (1)

University of Reading¹

01 Apr 2015-European Polymer Journal

TL;DR: From Wichterle’s pioneering work to the most recent hydrogel-based inventions and products on the market, it provides the reader with a detailed introduction to the topic and perspective on further potential developments.

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1,788 citations

Journal Article•DOI•

Engineered Nanoparticles for Drug Delivery in Cancer Therapy

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Tianmeng Sun¹, Yu Shrike Zhang¹, Bo Pang¹, Dong Choon Hyun¹, Miaoxin Yang², Younan Xia¹, Younan Xia² - Show less +3 more•Institutions (2)

The Wallace H. Coulter Department of Biomedical Engineering¹, Georgia Institute of Technology²

10 Nov 2014-Angewandte Chemie

TL;DR: It is anticipated that precisely engineered nanoparticles will emerge as the next-generation platform for cancer therapy and many other biomedical applications.

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Abstract: In medicine, nanotechnology has sparked a rapidly growing interest as it promises to solve a number of issues associated with conventional therapeutic agents, including their poor water solubility (at least, for most anticancer drugs), lack of targeting capability, nonspecific distribution, systemic toxicity, and low therapeutic index. Over the past several decades, remarkable progress has been made in the development and application of engineered nanoparticles to treat cancer more effectively. For example, therapeutic agents have been integrated with nanoparticles engineered with optimal sizes, shapes, and surface properties to increase their solubility, prolong their circulation half-life, improve their biodistribution, and reduce their immunogenicity. Nanoparticles and their payloads have also been favorably delivered into tumors by taking advantage of the pathophysiological conditions, such as the enhanced permeability and retention effect, and the spatial variations in the pH value. Additionally, targeting ligands (e.g., small organic molecules, peptides, antibodies, and nucleic acids) have been added to the surface of nanoparticles to specifically target cancerous cells through selective binding to the receptors overexpressed on their surface. Furthermore, it has been demonstrated that multiple types of therapeutic drugs and/or diagnostic agents (e.g., contrast agents) could be delivered through the same carrier to enable combination therapy with a potential to overcome multidrug resistance, and real-time readout on the treatment efficacy. It is anticipated that precisely engineered nanoparticles will emerge as the next-generation platform for cancer therapy and many other biomedical applications.

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1,603 citations

Journal Article•DOI•

Nanochemistry and Nanomedicine for Nanoparticle-based Diagnostics and Therapy

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Guanying Chen¹, Indrajit Roy², Chunhui Yang¹, Paras N. Prasad³•Institutions (3)

Harbin Institute of Technology¹, University of Delhi², State University of New York System³

22 Jan 2016-Chemical Reviews

TL;DR: This work presents a new generation of high-performance liquid chromatography platforms for selective separation of Na6(CO3) from Na4(SO4) through Na2SO4 and shows real-world applications in drug discovery and treatment of central nervous system disorders.

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Abstract: Diagnostics and Therapy Guanying Chen,‡,† Indrajit Roy,†,§ Chunhui Yang,*,‡ and Paras N. Prasad*,† †Institute for Lasers, Photonics, and Biophotonics and Department of Chemistry, University at Buffalo, State University of New York, Buffalo, New York 14260, United States ‡School of Chemical Engineering and Technology, Harbin Institute of Technology, Harbin, Heilongjiang 150001, China Department of Chemistry, University of Delhi, Delhi 110007, India

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1,123 citations

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References

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Open Access

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Book•

Principles of polymer chemistry

[...]

Paul J. Flory

01 Jan 1953

16,827 citations

"Hydrogel Nanoparticles in Drug Deli..." refers background in this paper

...), depending on the nature of the aqueous environment and polymer composition [30–33]....
[...]

Journal Article•DOI•

Hydrogels for biomedical applications.

[...]

Allan S. Hoffman¹•Institutions (1)

University of Washington¹

17 Jan 2002-Advanced Drug Delivery Reviews

TL;DR: The composition and synthesis of hydrogels, the character of their absorbed water, and permeation of solutes within their swollen matrices are reviewed to identify the most important properties relevant to their biomedical applications.

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5,173 citations

"Hydrogel Nanoparticles in Drug Deli..." refers background in this paper

...Ever-growing hydrogel technology has led to dramatic advances in pharmaceutical and biomedical era [22–25]....
[...]
...Pharmaceutical hydrogels have been categorized according to a variety of criteria mainly including, rout of administration [111–115], type of material being delivered [22,51,53], release kinetics [23,63–65], etc....
[...]
...The polymers commonly used in preparation of hydrogels with pharmaceutical and biological applications are from natural or synthetic origins [23,49–53]....
[...]

Journal Article•DOI•

Environment-sensitive hydrogels for drug delivery

[...]

Yong Qiu¹, Kinam Park¹•Institutions (1)

Purdue University¹

31 Dec 2001-Advanced Drug Delivery Reviews

TL;DR: Development of environmentally sensitive hydrogels with a wide array of desirable properties can be made is a formidable challenge, however, if the achievements of the past can be extrapolated into the future, it is highly likely that responsive hydrogelWith such properties can been made.

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4,216 citations

"Hydrogel Nanoparticles in Drug Deli..." refers background in this paper

...literature [49–51,53,54,91,92,94,95,63–65]....
[...]
...Temperature, electricity, light, pressure, sound, and magnetic field are among the physical stimuli of interest in this context, while pH, solvent composition, ions, and specific molecular recognition events are chemical stimuli reported so far [63–65]....
[...]
...Pharmaceutical hydrogels have been categorized according to a variety of criteria mainly including, rout of administration [111–115], type of material being delivered [22,51,53], release kinetics [23,63–65], etc....
[...]
...the hydrogel device itself [64]....
[...]
...On the other hand, chemical-responsive hydrogel systems propose several classes of hydrogels which can trigger drug release from a depot with respect to changes in the concentration of a specific molecule or bioactive compound in the surroundingmedia [63–65,77–84]....
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Journal Article•DOI•

Hydrogels in pharmaceutical formulations.

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Nicholas A. Peppas¹, Petr Bures¹, William Leobandung¹, Hideki Ichikawa²•Institutions (2)

Purdue University¹, Kobe Gakuin University²

03 Jul 2000-European Journal of Pharmaceutics and Biopharmaceutics

TL;DR: The aim of this article is to present a concise review on the applications of hydrogels in the pharmaceutical field, hydrogel characterization and analysis of drug release from such devices.

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3,484 citations

"Hydrogel Nanoparticles in Drug Deli..." refers background in this paper

...The polymers commonly used in preparation of hydrogels with pharmaceutical and biological applications are from natural or synthetic origins [23,49–53]....
[...]
...literature [49–51,53,54,91,92,94,95,63–65]....
[...]
...monomers most commonly used in the fabrication of hydrogel structures of pharmaceutical interest is shown in Table 2 [53]....
[...]
...Pharmaceutical hydrogels have been categorized according to a variety of criteria mainly including, rout of administration [111–115], type of material being delivered [22,51,53], release kinetics [23,63–65], etc....
[...]
...[53,55,62]....
[...]

Journal Article•

Long-Circulating and Target-Specific Nanoparticles: Theory to Practice

[...]

Seyed Moein Moghimi¹, A. C. Hunter¹, J. C. Murray²•Institutions (2)

University of Brighton¹, University of Nottingham²

01 Jun 2001-Pharmacological Reviews

TL;DR: The surface mechanisms, which affords red blood cells long-circulatory lives and the ability of specific microorganisms to evade macrophage recognition, are explored and the rational approaches in the design as well as the biological performance of such constructs are assessed.

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Abstract: The rapid recognition of intravenously injected colloidal carriers, such as liposomes and polymeric nanospheres from the blood by Kupffer cells, has initiated a surge of development for "Kupffer cell-evading" or long-circulating particles. Such carriers have applications in vascular drug delivery and release, site-specific targeting (passive as well as active targeting), as well as transfusion medicine. In this article we have critically reviewed and assessed the rational approaches in the design as well as the biological performance of such constructs. For engineering and design of long-circulating carriers, we have taken a lead from nature. Here, we have explored the surface mechanisms, which affords red blood cells long-circulatory lives and the ability of specific microorganisms to evade macrophage recognition. Our analysis is then centered where such strategies have been translated and fabricated to design a wide range of particulate carriers (e.g., nanospheres, liposomes, micelles, oil-in-water emulsions) with prolonged circulation and/or target specificity. With regard to the targeting issues, attention is particularly focused on the importance of physiological barriers and disease states.

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3,413 citations

"Hydrogel Nanoparticles in Drug Deli..." refers background in this paper

...In recent years, significant efforts have been devoted to use the potentials of nanotechnology in drug delivery since it offers a suitable means of site-specific and/or time-controlled delivery of small or large molecular weight drugs and other bioactive agents [1–9]....
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...providing targeted delivery of drugs, improving bioavailability, extending drug or gene effect in target tissue, and improving the stability of therapeutic agents against chemical/enzymatic degradation [3]....
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