Journal ArticleDOI
Hydrogen Sulfide Suppresses High Glucose-Induced Expression of Intercellular Adhesion Molecule-1 in Endothelial Cells
Qingbo Guan,Xiaolei Wang,Ling Gao,Jicui Chen,Yuantao Liu,Chunxiao Yu,Nan Zhang,Xu Zhang,Jiajun Zhao +8 more
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TLDR
Findings indicate that H2S might protect against HG-induced vascular damage by down-regulating ICAM-1 expression in endothelial cells.Abstract:
:Hydrogen sulfide (H2S) is a newly identified endogenous gasotransmitter that has been implicated in the pathophysiology of several biologic systems. However, the role of H2S in the pathogenesis of diabetic vascular injury remains unclear. The aims of this study were to determine the effectread more
Citations
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Role of Endothelial Dysfunction in Cardiovascular Diseases: The Link Between Inflammation and Hydrogen Sulfide
TL;DR: Hydrogen sulfide (H2S), an entry as a gasotransmitter, exerts diverse biological effects through acting on various targeted signaling pathways and is postulated to be a new indicator for endothelial cell inflammation and its associated endothelial dysfunction.
Journal ArticleDOI
Vascular biology of hydrogen sulfide
TL;DR: This review has focused on the impact of H2S on vascular structure and function with an emphasis on angiogenesis, vascular tone, vascular permeability and atherosclerosis.
Journal ArticleDOI
The role of H2S bioavailability in endothelial dysfunction.
TL;DR: The role of hydrogen sulfide (H2S) in the pathogenesis of EDF is reviewed, one of the fastest advancing research topics, and therapeutics aimed at remedying altered H2S bioavailability may benefit all.
Journal ArticleDOI
Regulation of mitochondrial bioenergetic function by hydrogen sulfide. Part II. Pathophysiological and therapeutic aspects
Katalin Módis,Eelke M. Bos,Enrico Calzia,Harry van Goor,Ciro Coletta,Andreas Papapetropoulos,Andreas Papapetropoulos,Mark R. Hellmich,Peter Radermacher,Frédéric Bouillaud,Csaba Szabó +10 more
TL;DR: The field of H2S‐induced therapeutic ‘suspended animation’ is overview, a concept in which a temporary pharmacological reduction in cell metabolism is achieved, producing a decreased oxygen demand for the experimental therapy of critical illness and/or organ transplantation.
Journal ArticleDOI
Anti-inflammatory and cytoprotective actions of hydrogen sulfide: translation to therapeutics.
John L. Wallace,Rory W. Blackler,Melissa V. Chan,Gabriela Jorge Da Silva,Wagdi Elsheikh,Kyle L. Flannigan,Iulia Gamaniek,Anna Manko,Lu Wang,Jean-Paul Motta,Andre G. Buret +10 more
TL;DR: There is a rapidly expanding body of evidence for important roles of hydrogen sulfide in protecting against tissue injury, reducing inflammation, and promoting repair, and there is strong evidence that novel, H2S-based therapeutics are safe and effective in animal models.
References
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Adhesion receptors of the immune system.
TL;DR: Three families of cell-surface molecules regulate the migration of lymphocytes and the interactions of activated cells during immune responses.
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Signaling to NF-kappaB.
Matthew S. Hayden,Sankar Ghosh +1 more
TL;DR: An overview of established NF-kappaB signaling pathways is provided with focus on the current state of research into the mechanisms that regulate IKK activation and NF- kappaB transcriptional activity.
Journal ArticleDOI
H2S as a Physiologic Vasorelaxant: Hypertension in Mice with Deletion of Cystathionine γ-Lyase
Guangdong Yang,Guangdong Yang,Lingyun Wu,Bo Jiang,Wei Yang,Jiansong Qi,Kun Cao,Qinghe Meng,Asif K. Mustafa,Weitong Mu,Shengming Zhang,Solomon H. Snyder,Rui Wang,Rui Wang +13 more
TL;DR: It is shown that H2S is physiologically generated by cystathionine γ-lyase (CSE) and that genetic deletion of this enzyme in mice markedly reduces H 2S levels in the serum, heart, aorta, and other tissues.
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Quantifying cellular oxidative stress by dichlorofluorescein assay using microplate reader.
Hong Wang,James A. Joseph +1 more
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The vasorelaxant effect of H2S as a novel endogenous gaseous KATP channel opener
TL;DR: It is demonstrated that H2S is an important endogenous vasoactive factor and the first identified gaseous opener of KATP channels in vascular SMCs and production from vascular tissues was enhanced by nitric oxide.