Hyperhomocysteinemia and Endothelial Dysfunction.
Citations
262 citations
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Cites background from "Hyperhomocysteinemia and Endothelia..."
...Not limited to coronary artery endothelium, endothelium generally are capable of producing vasodilators such as NO, prostacyclin (PGI2), and endothelium-derived hyperpolarizing factor (EDHF) as well as vasoconstrictors such as endothelin-1 (ET-1), angiotensin II (Ang II), and free radicals [2,41] that maintain the physiologically balanced vascular tone....
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109 citations
Cites background from "Hyperhomocysteinemia and Endothelia..."
...manifested by decreased bioavailability of endothelium-derived NO (Cheng et al., 2009)....
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...Hcy has been shown to alter NO metabolism, mainly manifested by decreased bioavailability of endothelium-derived NO (Cheng et al., 2009)....
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...Studies in cultured endothelial cells have shown that Hcy decreases NO bioavailability, which is correlated with impairment of NOmediated relaxation in hyperhomocysteinemia in animal models (Cheng et al., 2009)....
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...mediated relaxation in hyperhomocysteinemia in animal models (Cheng et al., 2009)....
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References
3,722 citations
"Hyperhomocysteinemia and Endothelia..." refers background in this paper
...Since then, abundant retrospective and prospective observational studies have shown a relation between plasma total homocysteine (tHcy) level and coronary artery disease, peripheral artery disease, stroke, or venous thrombosis [4,5]....
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...8-fold [4]....
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1,860 citations
"Hyperhomocysteinemia and Endothelia..." refers background in this paper
...McCully suggested that HHcy are causally related to cardiovascular diseases (CVD) in 1969 [2]....
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857 citations
"Hyperhomocysteinemia and Endothelia..." refers background in this paper
...Exposure of ECs to Hcy led to the formation of S-nitrosohomocysteine, decreasing the bioactivity of NO [24]....
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845 citations
"Hyperhomocysteinemia and Endothelia..." refers background in this paper
...Epoxyeicosatrienoic acid likely has a regulatory role in this pathway [35]....
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674 citations