Journal ArticleDOI
Hypoxia-inducible factor 1: master regulator of O2 homeostasis
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TLDR
Hypoxia-inducible factor 1 is a transcription factor that mediates essential homeostatic responses to reduced O2 availability in mammals and the effects of HIF-1 deficiency on cellular physiology and embryonic development are provided.About:
This article is published in Current Opinion in Genetics & Development.The article was published on 1998-10-01. It has received 1078 citations till now. The article focuses on the topics: Hypoxia-Inducible Factor 1 & Transcription factor.read more
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Angiogenesis in cancer and other diseases
Peter Carmeliet,Rakesh K. Jain +1 more
TL;DR: Pathological angiogenesis is a hallmark of cancer and various ischaemic and inflammatory diseases and integrated understanding is leading to the development of a number of exciting and bold approaches to treat cancer and other diseases, but owing to several unanswered questions, caution is needed.
Journal ArticleDOI
Why do cancers have high aerobic glycolysis
TL;DR: In this article, the authors propose that persistent metabolism of glucose to lactate even in aerobic conditions is an adaptation to intermittent hypoxia in pre-malignant lesions, which leads to microenvironmental acidosis requiring evolution to phenotypes resistant to acid-induced cell toxicity.
Journal ArticleDOI
Mechanisms of angiogenesis and arteriogenesis.
TL;DR: The cellular and molecular mechanisms underlying the formation of endothelium-lined channels and their maturation via recruitment of smooth muscle cells (arteriogenesis) during physiological and pathological conditions are summarized, alongside with possible therapeutic applications.
Journal ArticleDOI
Hypoxia-inducible factor-1 (HIF-1).
Qingdong Ke,Max Costa +1 more
TL;DR: Overexpression of HIF-1 has been found in various cancers, and targeting Hif-1 could represent a novel approach to cancer therapy.
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HIF prolyl‐hydroxylase 2 is the key oxygen sensor setting low steady‐state levels of HIF‐1α in normoxia
Edurne Berra,Emmanuel Benizri,Amandine Ginouvès,Véronique Volmat,Danièle Roux,Jacques Pouysségur +5 more
TL;DR: It is shown that specific ‘silencing’ of PHD2 with short interfering RNAs is sufficient to stabilize and activate HIF‐1α in normoxia in all the human cells investigated, concluding that, in vivo, PHDs have distinct assigned functions.
References
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Journal ArticleDOI
Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension
TL;DR: Hypoxia-inducible factor 1 (HIF-1) is found in mammalian cells cultured under reduced O2 tension and is necessary for transcriptional activation mediated by the erythropoietin gene enhancer in hypoxic cells.
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Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1.
Jo A. Forsythe,Bing-Hua Jiang,Narayan V. Iyer,Faton Agani,Sandra W. Leung,Robert D. Koos,Gregg L. Semenza +6 more
TL;DR: HIF-1 is implicate in the activation of VEGF transcription in hypoxic cells and this work demonstrates the involvement of Hif-1 in theactivation of V EGF transcription.
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A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation.
Gregg L. Semenza,Guang L. Wang +1 more
TL;DR: A functionally tripartite, 50-nt hypoxia-inducible enhancer which binds several nuclear factors, one of which is induced by Hypoxia via de novo protein synthesis.
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Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1α
Narayan V. Iyer,Lori E. Kotch,Faton Agani,Sandra W. Leung,Erik Laughner,Roland H. Wenger,Max Gassmann,John D. Gearhart,Ann M. Lawler,Aimee Y. Yu,Gregg L. Semenza +10 more
TL;DR: It is demonstrated that HIF-1alpha is a master regulator of cellular and developmental O2 homeostasis in Hif1a-/- embryos that manifested neural tube defects, cardiovascular malformations, and marked cell death within the cephalic mesenchyme.
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Purification and Characterization of Hypoxia-inducible Factor 1
Guang L. Wang,Gregg L. Semenza +1 more
TL;DR: The biochemical purification of HIF-1 from Epo-producing Hep3B cells and non-Epo-producing HeLa S3 cells concludes that in both cobalt chloride-treated HeLa cells and hypoxic Hep3 B cells HIF -1 is composed of two different subunits: 120-kDa Hif-1α and 91-94-k da HIF,1β.