Hzf and hCAS/CSE1L: making the right choice in p53-mediated tumour suppression.
Katherine E Ewings,Kevin M. Ryan +1 more
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This article is published in Cell Research.The article was published on 2007-10-01 and is currently open access. It has received 7 citations till now.read more
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A Homolog of the Cell Apoptosis Susceptibility Gene Involved in Ovary Development of Chinese Shrimp Fenneropenaeus chinensis
TL;DR: The cell apoptosis susceptibility (CAS) gene is a homolog of the yeast chromosome segregation (CSE1) gene, which functions in cell proliferation and apoptosis, which suggested that FcCAS might function as a nuclear protein.
Journal ArticleDOI
Role of Rad51 and DNA repair in cancer: A molecular perspective.
Erik Laurini,Domenico Marson,Alice Fermeglia,Suzana Aulic,Maurizio Fermeglia,Sabrina Pricl,Sabrina Pricl +6 more
TL;DR: An overview of the main DNA repair pathways, with special focus on the role played by homologous repair and the RAD51 recombinase protein in the cellular DNA damage response, and a survey of the most promising therapeutic strategies aimed at targeting RAD51 in experimental oncology.
Journal ArticleDOI
Effect of combined treatment with progesterone and tamoxifen on the growth and apoptosis of human ovarian cancer cells.
Ji-Young Lee,Jong Yeon Shin,Hyun-Seok Kim,Jee In Heo,Yoon Jung Kho,Hong-Jun Kang,Seong Hoon Park,Seong Hoon Park,Jae-Yong Lee +8 more
TL;DR: Results indicate that progesterone caused apoptosis and tamoxifen induced G1 arrest in ovarian cancer cells, indicating a synergistic effect on anti-cancer activity.
Journal ArticleDOI
Expression of CAS/CSE1L, the Cellular Apoptosis Susceptibility Protein, Correlates With Neoplastic Progression in Barrett's Esophagus.
Kun Jiang,Kevin G Neill,Daniel Cowden,Jason B. Klapman,Steven A. Eschrich,Jose M. Pimiento,Mokenge P. Malafa,Domenico Coppola +7 more
TL;DR: Findings show changes in CAS/CSE1L during BE progression, which may represent a potential marker for dysplasia/carcinoma and indicate its expression in BE neoplasia should be addressed.
Journal ArticleDOI
Cellular apoptosis susceptibility protein (CAS) suppresses the proliferation of breast cancer cells by upregulated cyp24a1.
TL;DR: Observations clarified the previous conflicting results on the cell fates of the breast cells regulated by CAS and provide new insight into the role of CAS in the development of breast cancer.
References
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Journal ArticleDOI
TIGAR, a p53-Inducible Regulator of Glycolysis and Apoptosis
Karim Bensaad,Atsushi Tsuruta,Mary A. Selak,M. Nieves Calvo Vidal,Katsunori Nakano,Ramon Bartrons,Eyal Gottlieb,Karen H. Vousden +7 more
TL;DR: expression of TIGAR may modulate the apoptotic response to p53, allowing survival in the face of mild or transient stress signals that may be reversed or repaired, and the decrease of intracellular ROS levels in response to TIGar may also play a role in the ability of p53 to protect from the accumulation of genomic damage.
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DRAM, a p53-Induced Modulator of Autophagy, Is Critical for Apoptosis
Diane Crighton,Simon Wilkinson,Jim O'Prey,Nelofer Syed,Paul D. Smith,Paul R. Harrison,Milena Gasco,Ornella Garrone,Tim Crook,Kevin M. Ryan +9 more
TL;DR: DRAM (damage-regulated autophagy modulator), a p53 target gene encoding a lysosomal protein that induces macroautophagy, is described as an effector of p53-mediated death and its relationship to p53 function and damage-induced programmed cell death is highlighted.
Journal ArticleDOI
ASPP proteins specifically stimulate the apoptotic function of p53.
Yardena Samuels-Lev,Daniel J. O'Connor,Daniele Bergamaschi,Giuseppe Trigiante,Jung-Kuang Hsieh,Shan Zhong,Isabelle Campargue,Louie Naumovski,Tim Crook,Xin Lu +9 more
TL;DR: The expression of ASPP is frequently downregulated in human breast carcinomas expressing wild-type p53 but not mutant p53, therefore, ASPP regulate the tumor suppression function of p53 in vivo.
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Genome-wide localization of the nuclear transport machinery couples transcriptional status and nuclear organization.
Jason M. Casolari,Christopher R. Brown,Suzanne Komili,Jason A. West,Haley Hieronymus,Pamela A. Silver +5 more
TL;DR: It is shown that transcriptional activation of the GAL genes results in their association with nuclear pore proteins, relocation to the nuclear periphery, and loss of RanGEF association, which indicates that the organization of the genome is coupled via transcriptional state to thenuclear transport machinery.
Journal ArticleDOI
iASPP oncoprotein is a key inhibitor of p53 conserved from worm to human
Daniele Bergamaschi,Yardena Samuels,Nigel J. O'Neil,Giuseppe Trigiante,Tim Crook,Jung-Kuang Hsieh,Daniel J. O'Connor,Shan Zhong,Isabelle Campargue,Matthew L. Tomlinson,Patricia E. Kuwabara,Xin Lu +11 more
TL;DR: iASPP is an evolutionarily conserved inhibitor of p53; inhibition of iASPP by RNA-mediated interference or antisense RNA in C. elegans or human cells, respectively, induces p53-dependent apoptosis and could provide an important new strategy for treating tumors expressing wild-type p53.