Hzf and hCAS/CSE1L: making the right choice in p53-mediated tumour suppression.
Katherine E Ewings,Kevin M. Ryan +1 more
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This article is published in Cell Research.The article was published on 2007-10-01 and is currently open access. It has received 7 citations till now.read more
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CAS protein expression in invasive breast ductal carcinoma and its relationship with cell proliferation and apoptosis: CAS protein expression in invasive breast ductal carcinoma and its relationship with cell proliferation and apoptosis
Effects of Arsenic Responsive P21 on Innate Immunity and Apoptosis in Zebrafish
TL;DR: The gene encoding for the protein p21, which had increased expression as a result of arsenic exposure from a previously complete microarray analysis, was characterized and increased the understanding of crucial apoptotic and cell cycle regulation pathways that may be altered as a consequence of exposure to 'safe' arsenic concentrations.
References
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Journal ArticleDOI
TIGAR, a p53-Inducible Regulator of Glycolysis and Apoptosis
Karim Bensaad,Atsushi Tsuruta,Mary A. Selak,M. Nieves Calvo Vidal,Katsunori Nakano,Ramon Bartrons,Eyal Gottlieb,Karen H. Vousden +7 more
TL;DR: expression of TIGAR may modulate the apoptotic response to p53, allowing survival in the face of mild or transient stress signals that may be reversed or repaired, and the decrease of intracellular ROS levels in response to TIGar may also play a role in the ability of p53 to protect from the accumulation of genomic damage.
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DRAM, a p53-Induced Modulator of Autophagy, Is Critical for Apoptosis
Diane Crighton,Simon Wilkinson,Jim O'Prey,Nelofer Syed,Paul D. Smith,Paul R. Harrison,Milena Gasco,Ornella Garrone,Tim Crook,Kevin M. Ryan +9 more
TL;DR: DRAM (damage-regulated autophagy modulator), a p53 target gene encoding a lysosomal protein that induces macroautophagy, is described as an effector of p53-mediated death and its relationship to p53 function and damage-induced programmed cell death is highlighted.
Journal ArticleDOI
ASPP proteins specifically stimulate the apoptotic function of p53.
Yardena Samuels-Lev,Daniel J. O'Connor,Daniele Bergamaschi,Giuseppe Trigiante,Jung-Kuang Hsieh,Shan Zhong,Isabelle Campargue,Louie Naumovski,Tim Crook,Xin Lu +9 more
TL;DR: The expression of ASPP is frequently downregulated in human breast carcinomas expressing wild-type p53 but not mutant p53, therefore, ASPP regulate the tumor suppression function of p53 in vivo.
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Genome-wide localization of the nuclear transport machinery couples transcriptional status and nuclear organization.
Jason M. Casolari,Christopher R. Brown,Suzanne Komili,Jason A. West,Haley Hieronymus,Pamela A. Silver +5 more
TL;DR: It is shown that transcriptional activation of the GAL genes results in their association with nuclear pore proteins, relocation to the nuclear periphery, and loss of RanGEF association, which indicates that the organization of the genome is coupled via transcriptional state to thenuclear transport machinery.
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iASPP oncoprotein is a key inhibitor of p53 conserved from worm to human
Daniele Bergamaschi,Yardena Samuels,Nigel J. O'Neil,Giuseppe Trigiante,Tim Crook,Jung-Kuang Hsieh,Daniel J. O'Connor,Shan Zhong,Isabelle Campargue,Matthew L. Tomlinson,Patricia E. Kuwabara,Xin Lu +11 more
TL;DR: iASPP is an evolutionarily conserved inhibitor of p53; inhibition of iASPP by RNA-mediated interference or antisense RNA in C. elegans or human cells, respectively, induces p53-dependent apoptosis and could provide an important new strategy for treating tumors expressing wild-type p53.