Journal ArticleDOI
Ibuprofen-based advanced therapeutics: breaking the inflammatory link in cancer, neurodegeneration, and diseases.
Arun Upadhyay,Ayeman Amanullah,Vibhuti Joshi,Rohan Dhiman,Vijay Kumar Prajapati,Krishna Mohan Poluri,Amit Mishra +6 more
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TLDR
Ibuprofen is a classical nonsteroidal anti-inflammatory drug (NSAID) highly prescribed to reduce acute pain and inflammation under an array of conditions, including rheumatoid arthritis, osteoarthritis, dysmenorrhea, and gout.Abstract:
Ibuprofen is a classical nonsteroidal anti-inflammatory drug (NSAID) highly prescribed to reduce acute pain and inflammation under an array of conditions, including rheumatoid arthritis, osteoarthritis, dysmenorrhea, and gout. Ibuprofen acts as a potential inhibitor for cyclooxygenase enzymes (COX-1 and COX-2). In the past few decades, research on this small molecule has led to identifying other possible therapeutic benefits. Anti-tumorigenic and neuroprotective functions of Ibuprofen are majorly recognized in recent literature and need further consideration. Additionally, several other roles of this anti-inflammatory molecule have been discovered and subjected to experimental assessment in various diseases. However, the major challenge faced by Ibuprofen and other drugs of similar classes is their side effects, and tendency to cause gastrointestinal injury, generate cardiovascular risks, modulate hepatic and acute kidney diseases. Future research should also be conducted to deduce new methods and approaches of suppressing the unwanted toxic changes mediated by these drugs and develop new therapeutic avenues so that these small molecules continue to serve the purposes. This article primarily aims to develop a comprehensive and better understanding of Ibuprofen, its pharmacological features, therapeutic benefits, and possible but less understood medicinal properties apart from major challenges in its future application.KEY POINTSIbuprofen, an NSAID, is a classical anti-inflammatory therapeutic agent.Pro-apoptotic roles of NSAIDs have been explored in detail in the past, holding the key in anti-cancer therapies.Excessive and continuous use of NSAIDs may have several side effects and multiple organ damage.Hyperactivated Inflammation initiates multifold detrimental changes in multiple pathological conditions.Targeting inflammatory pathways hold the key to several therapeutic strategies against many diseases, including cancer, microbial infections, multiple sclerosis, and many other brain diseases.read more
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Journal ArticleDOI
Elucidating the Neuroprotective Role of PPARs in Parkinson's Disease: A Neoteric and Prospective Target.
Tapan Behl,Piyush Madaan,Aayush Sehgal,Sukhbir Singh,Neelam Sharma,Saurabh Bhatia,Ahmed Al-Harrasi,Sridevi Chigurupati,Ibrahim Alrashdi,Simona Bungau +9 more
TL;DR: In this article, a review of the emerging evidence enlightening the neuroprotective outcomes of PPAR agonists in in vivo and in vitro models experiencing Parkinson's disease is presented.
Journal ArticleDOI
Novel 1,3-diaryl pyrazole derivatives bearing methylsulfonyl moiety: Design, synthesis, molecular docking and dynamics, with dual activities as anti-inflammatory and anticancer agents through selectively targeting COX-2.
Ahmed M. M. Shaker,Mai I. Shahin,Asmaa M. AboulMagd,Seham A. Abd-El-Aleem,Hamdy M. Abdel-Rahman,Dalal A. Abou El Ella +5 more
TL;DR: In this article , a series of novel 1-aryl-3-(4-methylsulfonylphenyl) pyrazole derivatives were synthesized, characterized by several spectroscopic techniques, and investigated as potential anti-inflammatory and anticancer agents.
Journal ArticleDOI
Synthesis of Ibuprofen Monoglyceride Using Novozym®435: Biocatalyst Activation and Stabilization in Multiphasic Systems
TL;DR: In this paper , the authors focused on the enzymatic esterification of glycerol and ibuprofen at high concentrations in two triphasic systems composed of toluene+ibuprofene (apolar) liquid phases, and a solid phase with the industrial immobilized lipase B from Candida antarctica named Novozym®435 (N435) acting as the biocatalyst.
Journal ArticleDOI
Zwitterion‐Catalyzed Ring‐Opening of Epoxides with Carboxylic Acids
Journal ArticleDOI
The Effects of 2′-Hydroxy-3,6′-Dimethoxychalcone on Melanogenesis and Inflammation
Su Mi Bae,Chang-Gu Hyun +1 more
TL;DR: In this article , the effect of 3,6′-dimethoxychalcone on melanogenesis and lipopolysaccharides (LPS)-induced inflammation in mouse B16F10 and RAW 264.7 cells was investigated.
References
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Journal ArticleDOI
Effect of ibuprofen dosage on patient response in rheumatoid arthritis.
TL;DR: In a 4-week double-blind trial in 41 patients with rheumatoid arthritis, ibuprofen (Motrin) decreased the swollen joint count significantly at a dosage level of 2400 mg/ day, but not at 1200 mg/day.
Journal ArticleDOI
Ibuprofen is deleterious for the development of first trimester human fetal ovary ex vivo
S. Leverrier-Penna,Rod T. Mitchell,Emmanuelle Becker,Laetitia L Lecante,M. Ben Maamar,Natalie Z.M. Homer,Vincent Lavoué,David Møbjerg Kristensen,Nathalie Dejucq-Rainsford,Bernard Jégou,Bernard Jégou,Séverine Mazaud-Guittot +11 more
TL;DR: The results points to a deleterious effect of this drug on first trimester fetal ovaries ex vivo, and reveal the urgent need for further investigations on the cellular and molecular mechanisms that underlie the effect of ibuprofen on fetal ovary development.
Journal ArticleDOI
Ibuprofen and Lipoic Acid Diamide as Co-Drug with Neuroprotective Activity: Pharmacological Properties and Effects in β-Amyloid (1–40) Infused Alzheimer's Disease Rat Model
A. Di Stefano,P. Sozio,Laura Serafina Cerasa,A. Iannitelli,Amelia Cataldi,Susi Zara,Gianfabio Giorgioni,Cinzia Nasuti +7 more
TL;DR: The present findings suggest that co-drug 1 treatment may protect against the cognitive dysfunction induced by intracerebroventricular infusion of β-amyloid (1–40) in rats, and could prove useful as a tool for controlling Alzheimer's disease-induced cerebral amyloid deposits and behavioural deterioration.
Journal ArticleDOI
Ibuprofen Treatment Reduces the Neuroinflammatory Response and Associated Neuronal and White Matter Impairment in the Growth Restricted Newborn.
Julie A. Wixey,Kishen R. Sukumar,Rinaldi Pretorius,Kah Meng Lee,Paul B. Colditz,Paul B. Colditz,S. Tracey Bjorkman,Kirat K. Chand +7 more
TL;DR: It is demonstrated ibuprofen reduces the inflammatory response in the IUGR neonatal brain and concurrently reduces neuronal and white matter impairment.
Journal ArticleDOI
Review of Ibuprofen for Osteoarthritis
Roy D. Altman,Roy D. Altman +1 more
TL;DR: Tolerability was consistently excellent with ibuprofen, and adverse reactions were few, in trials with a wide variety of other nonsteroidal anti-inflammatory drugs, and ib uprofen was often as effective as the comparison agent.
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