Identification and in silico analysis of functional SNPs of the BRCA1 gene.
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Cites background from "Identification and in silico analys..."
...…and demonstrated their potential effect on protein structure, function, and stability (Sang et al. 2016; Agrahari and George Priya Doss 2015; Bhardwaj et al. 2016; Tekcan 2016; Bakhit et al. 2016; Rajasekaran et al. 2007; Doss and Sethumadhavan 2009; Zaki et al. 2017a, b; Mosaeilhy et al. 2017)....
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48 citations
Cites methods from "Identification and in silico analys..."
...Similar approach has been used to investigate the effect of nsSNP of BARD1gene and BRCA1 gene (Ali et al., 2012; Rajasekaran et al., 2007)....
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References
6,449 citations
"Identification and in silico analys..." refers methods in this paper
...The SNPs and their related protein sequence for the BRCA1 gene were obtained from the dbSNP [8] (http://www....
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...The BRCA1 gene investigated in this work was retrieved from the dbSNP database [8]....
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5,318 citations
"Identification and in silico analys..." refers background or methods in this paper
...We used the program SIFT [9] available at http://blocks....
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...Hence, changes at well-conserved positions tend to be predicted as deleterious [9]....
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...The conservation level of a particular position in a protein was determined by using a sequence homology-based tool, SIFT [9]....
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2,443 citations
"Identification and in silico analys..." refers background in this paper
...Also, nsSNPs affect the functional roles of proteins in the signal transduction of visual, hormonal, and other stimulants [5,6]....
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2,374 citations
"Identification and in silico analys..." refers background in this paper
...Substitutions at each position with normalized probabilities less than a chosen cutoff are predicted to be deleterious and those greater than or equal to the cutoff are predicted to be tolerated [10]....
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