Identification and prospective validation of clinically relevant chronic obstructive pulmonary disease (COPD) subtypes
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...However, our findings are consistent with those of Garcia-Aymerich et al, who using a different methodological approach (cluster analysis) also identified a ‘‘systemic’’ COPD subtype characterized by more systemic inflammation and a higher proportion of obesity in 342 COPD patients followed during 4 years [42]....
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"Identification and prospective vali..." refers background in this paper
...From a total of 536 variables obtained, 224 were considered after excluding those with additive relationships or resulting from categorisations. Since missing values made up a small proportion and were considered to be either completely random or random,...
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...7).(3) The protocol was approved by the Ethics Committees of all the participating hospitals, and written informed consent was obtained from all subjects....
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