Identification and proteomic profiling of exosomes in human urine
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..., 2005), urine (Pisitkun et al., 2004), saliva (Ogawa et al....
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...…from diverse body fluids, including semen (Ronquist and Brody, 1985; Park et al., 2011; Aalberts et al., 2012), blood (Caby et al., 2005), urine (Pisitkun et al., 2004), saliva (Ogawa et al., 2011), breast milk (Admyre et al., 2007), amniotic fluid (Asea et al., 2008), ascites fluid (Andre et…...
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4,492 citations
Cites background from "Identification and proteomic profil..."
...…Van Niel et al., 2003; Wubboltz et al., 2003; Amzallag et al., 2004; Fevrier et al., 2004; Hegmans et al., 2004; Mears et al., 2004; Segura et al., 2005), primary cells (Heijnen et al., 1999; de Gassart et al., 2003), or bodily fluids (Bard et al., 2004; Pisitkun et al., 2004; Caby et al., 2005)....
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3,690 citations
Cites background from "Identification and proteomic profil..."
...However, it was as recent as 2004 that urinary EVs were first depicted as such (18) and it has now been estimated that only about 3% of the total urinary protein content is derived from EVs....
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...colon cancer cell line LIM1215 (28), urine (18,38) and...
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...The urinary EV cargo suggests that cells along the renal epithelium, extending from the glomerular podocytes (249,250) through the proximal tubule, the thick ascending limb of Henle, the distal convoluted tubule and the collecting duct, are releasing EVs into urine (18,38)....
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...An additional role for EVs in kidney physiology seems to be is through direct actions of EV-resident proteins in the renal tubule lumen (257), such as the angiotensin-converting enzyme (18,38), which could have a role in the renin angiotensin system hence playing a role in water (fluid) balance....
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...(56), plasma (55) and urine (18,38) EVs has been reported....
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3,441 citations
References
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