Identification of 42 Genes Linked to Stage II Colorectal Cancer Metastatic Relapse
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Cites background from "Identification of 42 Genes Linked t..."
...It has been reported that ADRA1A is highly expressed in peripheral blood vessels of patients with uterine cancer, and ADRA1A regulates proliferation, inhibits tumor formation/metastasis (Al‐Temaimi et al., 2016)....
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Cites background from "Identification of 42 Genes Linked t..."
...Despite identifying numerous genes that affect the recurrence and metastasis of CRC [18, 19], no prognostic gene signature has been validated so far....
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References
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"Identification of 42 Genes Linked t..." refers methods in this paper
...The normalized data was compiled and subsequently standardized using ComBat to remove batch effects [40]....
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"Identification of 42 Genes Linked t..." refers methods in this paper
...Briefly, a curated EMT gene set [42], after removing basal keratins genes [43,44], was used as an initial selection of epithelial and mesenchymal cell lines....
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1,008 citations
"Identification of 42 Genes Linked t..." refers background in this paper
...EMT fundamentally involves genomic and phenotypic changes of epithelial cells into mesenchymal cells, loss of epithelial cell-cell contact, loss of cell polarity, and acquisition of migratory characteristics facilitating metastasis [17]....
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960 citations
"Identification of 42 Genes Linked t..." refers background in this paper
...Activation of EMT was shown to reduce cell proliferation by targeting specific pro-proliferation genes [28,29]....
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