Identification of a Cancer Stem Cell in Human Brain Tumors
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7,120 citations
Cites background from "Identification of a Cancer Stem Cel..."
...Recently, we prospectively isolated a CD133 p cell subpopulation from human brain tumours that exhibited stem cell properties in vitro...
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5,771 citations
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3,480 citations
3,289 citations
References
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"Identification of a Cancer Stem Cel..." refers background in this paper
...Somatic stem cells are thought to self-renew to generate all of the mature cell types of a particular tissue through differentiation, although rigorous identification and isolation of tissue-specific stem cells has been accomplished prospectively in only a few organ systems (2)....
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...The concept of the cancer stem cell arose from the observation of striking similarities between the self-renewal mechanisms of stem cells and cancer cells (2)....
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...There is overwhelming evidence in other malignancies, such as leukemia, that the clonal population of neoplastic cells exhibits marked heterogeneity with respect to proliferation and differentiation (1, 2)....
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...Moreover, if a tumor is viewed as an aberrant organ initiated by a cancer stem cell (2), then the role of the tumor stem cell would be necessarily lineage-restricted to generate only the mature cells that comprise the tumor....
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...Because normal somatic stem cells must self-renew and maintain a relative balance between self-renewal and differentiation, cancer can be contextualized as a disease of unregulated self-renewal (2)....
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6,709 citations
"Identification of a Cancer Stem Cel..." refers background in this paper
...The ability to fractionate and functionally analyze leukemic stem cells led to the determination that they are necessary and sufficient to maintain the leukemia (1, 3)....
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...In malignancies such as leukemia (1), multiple myeloma (28), and most recently breast cancer (29), rare cells were isolated with a remarkable potential for self-renewal, and these cells alone were found to drive the formation and growth of tumors....
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...There is overwhelming evidence in other malignancies, such as leukemia, that the clonal population of neoplastic cells exhibits marked heterogeneity with respect to proliferation and differentiation (1, 2)....
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5,497 citations
"Identification of a Cancer Stem Cel..." refers background or methods in this paper
...chemically defined serum-free neural stem cell medium (4), human recombi-...
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...We used culture conditions that favored stem cell growth, established previously for isolation of neural stem cells as neurospheres (4)....
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4,597 citations
"Identification of a Cancer Stem Cel..." refers background in this paper
...The ability to fractionate and functionally analyze leukemic stem cells led to the determination that they are necessary and sufficient to maintain the leukemia (1, 3 )....
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