Identification of a monoclonal antibody specific for a murine T3 polypeptide
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TLDR
Results identify T3-epsilon as a cell surface protein involved in the transduction of activation signals and can both activate and inhibit T-cell function.Abstract:
A monoclonal antibody (145-2C11) specific for the murine T3 complex was derived by immunizing Armenian hamsters with a murine cytolytic T-cell clone. The antibody is specific for a 25-kDa protein component (T3-epsilon) of the antigen-specific T-cell receptor. It reacts with all mature T cells and can both activate and inhibit T-cell function. These results identify T3-epsilon as a cell surface protein involved in the transduction of activation signals.read more
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B7/CD28 costimulation is essential for the homeostasis of the CD4+CD25+ immunoregulatory T cells that control autoimmune diabetes.
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References
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Identification of a putative second T-cell receptor.
Michael B. Brenner,Michael B. Brenner,Joanne McLean,Deno P. Dialynas,Jack L. Strominger,John A. Smith,Frances L. Owen,Jonathan G. Seidman,Stephen C.Y. Ip,Fred S. Rosen,Michael S. Krangel +10 more
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The Molecular Genetics of the T-Cell Antigen Receptor and T-Cell Antigen Recognition
TL;DR: The genes encoding the alpha and beta chain of the T-cell receptor and the gamma gene have been cloned, and their structure, organization, ontogeny of expression, pattern of rearrangement, and diversification are now generally understood.
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Transmembrane signalling by the T cell antigen receptor. Perturbation of the T3-antigen receptor complex generates inositol phosphates and releases calcium ions from intracellular stores.
John B. Imboden,John D. Stobo +1 more
TL;DR: Data indicate that, during activation, perturbation of the T3-antigen receptor complex generates inositol trisphosphate, which functions as an intracellular signal to release Ca2+ from intrACEllular stores, leading to increases in [Ca2+]i.
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OKT3: a monoclonal anti-human T lymphocyte antibody with potent mitogenic properties.
TL;DR: The cell membrane determinant recognized by OKT3 could be described as a "T cell stimulation receptor" as this interaction can trigger mitogenesis, the mitogenecity of the lymphocytes is not solely dependent on cross-linking of these receptors.
Journal ArticleDOI
Expression of interleukin-2 receptors as a differentiation marker on intrathymic stem cells.
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