Identification of a signal transducer and activator of transcription (STAT) binding site in the mouse metallothionein-I promoter involved in interleukin-6-induced gene expression.
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Cites background from "Identification of a signal transduc..."
..., 2001) and STAT binding sites are present on the Mt promoter (Lee et al., 1999)....
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...GM-CSF signals through STAT5 (Bhattacharya et al., 2001) and STAT binding sites are present on the Mt promoter (Lee et al., 1999)....
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174 citations
Cites background from "Identification of a signal transduc..."
...…both cytokines regulate MT-I/II expression, which is in line with results obtained with transgenic mice overexpressing either IL-6 (Carrasco et al., 1999; Hernandez et al., 1997) or TNF-α (Carrasco et al., 2000a) and with the presence of STAT response elements in the promoters (Lee et al., 1999)....
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...Increased levels of MT-I/II in response to inflammatory factors is very likely to be influenced by cytokines such as interleukin (IL-6) through signal transducer and activator of transcription (STAT) factors (Lee et al., 1999)....
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...Increased levels of MT-I/II in response to inflammatory factors is very likely to be influenced by cytokines such as interleukin (IL-6) through signal transducer and activator of transcription (STAT) factors (Lee et al., 1999).....
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..., 2000a) and with the presence of STAT response elements in the promoters (Lee et al., 1999)....
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155 citations
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