Identification of dengue viral RNA-dependent RNA polymerase inhibitor using computational fragment-based approaches and molecular dynamics study.
Citations
335 citations
87 citations
76 citations
56 citations
Cites background from "Identification of dengue viral RNA-..."
...The human body does not contain an RdRp enzyme or analogs of it, thus inhibitors may not cause severe toxic effects, making it an optimal target in drug design (Shanmugam et al., 2016)....
[...]
50 citations
References
3,658 citations
1,309 citations
662 citations
"Identification of dengue viral RNA-..." refers background in this paper
...An anticancer drug Zelboraf (Vemurafenib) approved by FDA is a milestone in the success history of FBDD (Bollag et al., 2012)....
[...]
...Fragment-based drug designing (FBDD) has emerged as an efficient method in drug discovery and design....
[...]
...This makes GFL suitable for FBDD and was downloaded from Enamine database in structure data file format (sdf)....
[...]
...The availability of suitable high-throughput screening approaches, sensitive biophysical techniques such as nuclear magnetic resonance and X-ray crystallography and best optimization strategies makes FBDD a powerful tool for finding good quality hits for a wide range of drug targets (Kumar, Voet, & Zhang, 2012)....
[...]
...We applied FBDD technique and identified a potent inhibitor for DV RdRp enzyme....
[...]
660 citations
399 citations
"Identification of dengue viral RNA-..." refers background in this paper
...Four closely related but antigenically distinct serotypes of dengue virus (DV 1-4) causes dengue infection (Weaver & Vasilakis, 2009)....
[...]