Identification of microRNAs controlling human ovarian cell steroidogenesis via a genome-scale screen.
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..., but none that stimulated E2 release [58]....
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...BPA down-regulated miR-137 may decrease sex steroid hormone synthesis (112) and miR-765 may be associated with premature ovarian failure (113, 114)....
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References
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"Identification of microRNAs control..." refers background in this paper
...In humans, miRNA genes, which represent approximately 1–3% of genes, may regulate up to 90% of all genes (Bartel, 2004; Silveri et al., 2006; Stefani and Slack, 2006; Mattes et al., 2007; Farazi et al., 2008). miRNA precursors (pre-miRNAs) generated in the nucleus are exported to the cytoplasm,…...
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...Interestingly, mir-122 was able to reduce plasma cholesterol level and hepatic cholesterol synthesis (Bartel, 2004) suggesting that it could inhibit steroidogenesis via suppression of relatively independent processes in different tissues— inhibition of cholesterol synthesis in liver, transport of…...
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"Identification of microRNAs control..." refers background in this paper
...…production by megakaryoblasts (Guimaraes-Sternberg et al., 2006), plasma cholesterol level (Mattes et al., 2007) and on expression of peptides related to regeneration and insulin output in pancreatic cells (Poy et al., 2004; Plaisance et al., 2006; Baroukh et al., 2007; Joglekar et al., 2007)....
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"Identification of microRNAs control..." refers background in this paper
...…has been reported previously. miR-15a was shown to promote apoptosis through suppression of bcl-2 and other pro-proliferating and antiapoptotic substance and probably prevents proliferation and malignant transformation of lymphocytes and prostate cells (Bonci et al., 2008; Calin et al., 2008)....
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768 citations
"Identification of microRNAs control..." refers background in this paper
...…has been reported previously. miR-15a was shown to promote apoptosis through suppression of bcl-2 and other pro-proliferating and antiapoptotic substance and probably prevents proliferation and malignant transformation of lymphocytes and prostate cells (Bonci et al., 2008; Calin et al., 2008)....
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