Identification of potential inhibitors against SARS-CoV-2 by targeting proteins responsible for envelope formation and virion assembly using docking based virtual screening, and pharmacokinetics approaches.
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TLDR
Rutin, a bioflavonoid and the antibiotic, doxycycline, is identified as the most potent inhibitor of SARS-CoV-2 envelope protein, which is a essential role in the assembly and formation of the infectious virion particles.About:
This article is published in Infection, Genetics and Evolution.The article was published on 2020-10-01 and is currently open access. It has received 83 citations till now. The article focuses on the topics: Virion assembly & Membrane protein.read more
Citations
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Magnetic beads combined with carbon black-based screen-printed electrodes for COVID-19: A reliable and miniaturized electrochemical immunosensor for SARS-CoV-2 detection in saliva
Laura Fabiani,Marco Saroglia,Giuseppe Galatà,Riccardo De Santis,Silvia Fillo,Vincenzo Luca,Giovanni Faggioni,Nino D'Amore,Elisa Regalbuto,Piero Salvatori,Genciana Terova,Danila Moscone,Florigio Lista,Fabiana Arduini +13 more
TL;DR: This analytical tool has high potentiality for market entry as the first highly sensitive electrochemical immunoassay for SARS-CoV-2 detection in untreated saliva.
Journal ArticleDOI
Identifying the natural polyphenol catechin as a multi-targeted agent against SARS-CoV-2 for the plausible therapy of COVID-19: an integrated computational approach.
Chandra Bhushan Mishra,Preeti Pandey,Ravi Datta Sharma,Zubbair Malik,Raj Kumar Mongre,Andrew M. Lynn,Rajendra Prasad,Raok Jeon,Amresh Prakash +8 more
TL;DR: In this article, the authors report a comprehensive computational approach to identify the multi-targeted drug molecules against the SARS-CoV-2 proteins, which are crucially involved in the viral-host interaction, replication of the virus inside the host, disease progression and transmission of coronavirus infection.
Journal ArticleDOI
Nucleic Acid-Based Diagnostic Tests for the Detection SARS-CoV-2: An Update.
TL;DR: In this article, the authors present an objective overview of the latest nucleic acid-based diagnostic tests for the detection of SARS-CoV-2 that have been authorized by the Food and Drug Administration (FDA) under emergency use authorization (EUA) as of 31 October 2020.
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Multidisciplinary Approaches Identify Compounds that Bind to Human ACE2 or SARS-CoV-2 Spike Protein as Candidates to Block SARS-CoV-2-ACE2 Receptor Interactions.
Christopher J. Day,Benjamin Bailly,Patrice Guillon,Larissa Dirr,Freda E.-C. Jen,Belinda L. Spillings,Johnson Mak,Mark von Itzstein,Thomas Haselhorst,Michael P. Jennings +9 more
TL;DR: In this article, a dual strategy of molecular docking and surface plasmon resonance (SPR) screening of compound libraries was used to identify those that bind to human ACE2 or the SARS-CoV-2 spike protein receptor binding domain (RBD).
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In silico identification of Tretinoin as a SARS-CoV-2 envelope (E) protein ion channel inhibitor.
TL;DR: The possibility of exploring Tretinoin as a potential SARS-CoV-2 E protein ion channel blocker and virus assembly inhibitor is highlighted, which could be an important therapeutic strategy in the treatment for coronaviruses.
References
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