Identification of White Adipocyte Progenitor Cells In Vivo
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TLDR
The identification of an undifferentiated adipocyte precursor subpopulation resident within the adipose tissue stroma that is capable of proliferating and differentiating into an adipose depot in vivo is provided.About:
This article is published in Cell.The article was published on 2008-10-17 and is currently open access. It has received 836 citations till now. The article focuses on the topics: Adipocyte & 3T3-L1.read more
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Beige Adipocytes Are a Distinct Type of Thermogenic Fat Cell in Mouse and Human
Jun Wu,Pontus Boström,Lauren M. Sparks,Li Ye,Jang Hyun Choi,An Hoa Giang,Melin J. Khandekar,Kirsi A. Virtanen,Pirjo Nuutila,Gert Schaart,Kexin Huang,Hua Tu,Wouter D. van Marken Lichtenbelt,Joris Hoeks,Sven Enerbäck,Patrick Schrauwen,Bruce M. Spiegelman +16 more
TL;DR: Beige cells have a gene expression pattern distinct from either white or brown fat and are preferentially sensitive to the polypeptide hormone irisin, providing evidence that previously identified brown fat deposits in adult humans are composed of beige adipocytes.
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What We Talk About When We Talk About Fat
TL;DR: New perspective is gained on the roles played by adipocyte in a variety of homeostatic processes and on the mechanisms used by adipocytes to communicate with other tissues and how these relationships are altered during metabolic disease and how they might be manipulated to restore metabolic health.
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Satellite Cells and the Muscle Stem Cell Niche
TL;DR: For the last half century, the advance of molecular biology, cell biology, and genetics has greatly improved the understanding of skeletal muscle biology, with focuses on functions of satellite cells and their niche during the process ofletal muscle regeneration.
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Adipose tissue remodeling and obesity
TL;DR: There are remarkable similarities between adipose expansion and growth of solid tumors, a phenomenon that presents both an opportunity and a challenge, since pharmacological interventions supporting healthy adipose tissue adaptation can also facilitate tumor growth.
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The MSC: An Injury Drugstore
Arnold I. Caplan,Diego Correa +1 more
TL;DR: Evidence that leads to the proposal that during local injury, MSCs are released from their perivascular location, become activated, and establish a regenerative microenvironment by secreting bioactive molecules and regulating the local immune response is discussed.
References
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Multilineage cells from human adipose tissue: implications for cell-based therapies.
Patricia A. Zuk,Min Zhu,Hiroshi Mizuno,Jerry I. Huang,Futrell Jw,Adam J. Katz,Prosper Benhaim,H. P. Lorenz,Marc H. Hedrick +8 more
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Obesity as a medical problem
TL;DR: The global epidemic of obesity results from a combination of genetic susceptibility, increased availability of high-energy foods and decreased requirement for physical activity in modern society, and should be regarded as an epidemic that threatens global well being.
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Metabolism of isolated fat cells. i. effects of hormones on glucose metabolism and lipolysis.
The Metabolism of Isolated Fat Cells: I. Effects of Hormones on Glucose Metabolism and Lipolysis
TL;DR: This article marks the beginning of Rodbell's interest in cell receptors and related his discovery that fat cells could be isolated from other cells by treating them with preparations of collagenase, and also found that insulin could stimulate glucose uptake.