IFN-α-driven CCL2 production recruits inflammatory monocytes to infection site in mice
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TLDR
CCL2 expression driven by IFI-16 recognition of HSV-1 facilitates the recruitment of inflammatory monocytes into the cornea proper to control viral replication.About:
This article is published in Mucosal Immunology.The article was published on 2013-01-01 and is currently open access. It has received 82 citations till now. The article focuses on the topics: Chemokine & Viral replication.read more
Citations
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Journal ArticleDOI
The regulation of inflammation by interferons and their STATs
TL;DR: The goal of this review is to give an overview of the different facets of the inflammatory process that show regulatory input by IFN/STAT.
Journal ArticleDOI
Alveolar macrophage–derived type I interferons orchestrate innate immunity to RSV through recruitment of antiviral monocytes
Michelle Goritzka,Spyridon Makris,Fahima Kausar,Lydia Durant,Catherine Pereira,Yutaro Kumagai,Fiona J. Culley,Matthias Mack,Shizuo Akira,Cecilia Johansson +9 more
TL;DR: It is demonstrated that this role for recruited inflammatory monocytes in antiviral immunity and protection from RSV infection in mice is critically dependent on the production of type I IFNs by alveolar macrophages triggered via RIG-I–like receptors, thus highlighting an important cell-extrinsic mechanism oftype I IFN–mediated antiviral activity.
Journal ArticleDOI
Dynamic control of type I IFN signalling by an integrated network of negative regulators
TL;DR: Evidence is reviewed for an integrated network of negative regulators of IFN production and action, which function at all levels of the activating and effector signalling pathways, to limit tissue damage while enabling an IFN response that is temporally appropriate and of sufficient magnitude.
Journal ArticleDOI
Global virus outbreaks: Interferons as 1st responders
TL;DR: Given the direct antiviral effects of type I interferons (IFNs) in inhibiting the replication of both DNA and RNA viruses at different stages of their replicative cycles, and the effects oftype I IFNs on activating immune cell populations to clear virus infections, IFNs-α/β present as ideal candidate broad-spectrum antivirals.
Journal ArticleDOI
Phenolic Glycolipid Facilitates Mycobacterial Escape from Microbicidal Tissue-Resident Macrophages
C.J. Cambier,C.J. Cambier,C.J. Cambier,Seónadh O'Leary,Mary P. O'Sullivan,Joseph Keane,Lalita Ramakrishnan +6 more
TL;DR: A critical role for mycobacterial membrane phenolic glycolipid (PGL) in engineering this transition to lung alveolar macrophages is defined, arguing for the potential of PGL-blocking interventions or P GL-targeting vaccine strategies in the prevention of tuberculosis.
References
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Journal ArticleDOI
CCL2 recruits inflammatory monocytes to facilitate breast-tumour metastasis
Bin-Zhi Qian,Jiufeng Li,Hui Zhang,Takanori Kitamura,Jinghang Zhang,Liam Campion,Elizabeth Kaiser,Linda A. Snyder,Jeffrey W. Pollard +8 more
TL;DR: The mechanistic link between CCL2 expression and macrophage infiltration are correlated with poor prognosis and metastatic disease in human breast cancer and the origin of these macrophages is defined by showing that Gr1-positive inflammatory monocytes are preferentially recruited to pulmonary metastases but not to primary mammary tumours in mice.
Journal ArticleDOI
Targeted Disruption of the MyD88 Gene Results in Loss of IL-1- and IL-18-Mediated Function
Osamu Adachi,Taro Kawai,Kiyoshi Takeda,Makoto Matsumoto,Hiroko Tsutsui,Masafumi Sakagami,Kenji Nakanishi,Shizuo Akira +7 more
TL;DR: It is demonstrated that MyD88 is a critical component in the signaling cascade that is mediated by IL-1 receptor as well as IL-18 receptor, and increases in interferon-gamma production and natural killer cell activity in response to IL- 18 are abrogated.
Journal ArticleDOI
IFI16 is an innate immune sensor for intracellular DNA.
Leonie Unterholzner,Sinead E. Keating,Marcin Baran,Kristy A. Horan,Søren B. Jensen,Søren B. Jensen,Shrutie Sharma,Cherilyn M. Sirois,Tengchuan Jin,Eicke Latz,Eicke Latz,T. Sam Xiao,Katherine A. Fitzgerald,Søren R. Paludan,Andrew G. Bowie +14 more
TL;DR: IFI16 (p204) is the first PYHIN protein to their knowledge shown to be involved in IFN-β induction and forms a new family of innate DNA sensors the authors call 'AIM2-like receptors' (ALRs).
Journal ArticleDOI
Inhibition of viral replication by interferon-gamma-induced nitric oxide synthase
Gunasegaran Karupiah,Qiao-wen Xie,R. M. L. Buller,Carl Nathan,C. J. Duarte,John D. MacMicking +5 more
TL;DR: Induction of NO synthase can be necessary and sufficient for a substantial antiviral effect of IFN-gamma and converted resolving ectromelia virus infection into fulminant mousepox in mice.
Journal ArticleDOI
Absence of Monocyte Chemoattractant Protein 1 in Mice Leads to Decreased Local Macrophage Recruitment and Antigen-Specific T Helper Cell Type 1 Immune Response in Experimental Autoimmune Encephalomyelitis
TL;DR: It is demonstrated that MCP-1 is crucial for Th1 immune responses in EAE induction and that macrophage recruitment to the inflamed CNS target organ is required for primed T cells to execute a Th1 effector program in Eae.
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