IGF2BP1 is a targetable SRC/MAPK-dependent driver of invasive growth in ovarian cancer
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"IGF2BP1 is a targetable SRC/MAPK-de..." refers methods in this paper
...IGF2BP1 staining was determined blinded by two pathologists using the immunoreactive score as described [50]: 0 – absent; 1-4 – weak; 5-8 – moderate; 9-12 – strong expression....
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"IGF2BP1 is a targetable SRC/MAPK-de..." refers background in this paper
...This identifies IGF2BP1 as a novel marker of the mesenchymal-like C5 subtype of HGSOCs [12]....
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...Enhanced expression of IGF2BP1 is associated with a mesenchymal/proliferative-like gene signature observed in approximately 30% of serous ovarian cancers [6,12,13]....
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...Considering the major problem of invasive growth associated with ovarian cancer spread in the abdominal cavity, the further investigation of IGF2BP1-driven cancer progression, in particular its roles in the mesenchymal subtype of HGSOCs, appears mandatory....
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...Unsupervised clustering of patient samples by transcriptome data identified molecular subtypes of HGSOCs with distinct characteristics, including an invasive, mesenchymallike subtype, observed in approximately 30% of patients [1,6,12,13]....
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