IgH-V(D)J NGS-MRD measurement pre- and early post-allotransplant defines very low- and very high-risk ALL patients
Michael A. Pulsipher,Christopher S. Carlson,Bryan Langholz,Donna A. Wall,Kirk R. Schultz,Nancy Bunin,Ilan R. Kirsch,Julie M. Gastier-Foster,Michael J. Borowitz,Cindy Desmarais,David Williamson,Michael Kalos,Stephan A. Grupp +12 more
Reads0
Chats0
TLDR
Post-HCT NGS-MRD detection is highly predictive of relapse and survival, suggesting a role for this technique in defining patients early who would be eligible for post- HCT interventions.About:
This article is published in Blood.The article was published on 2015-05-28 and is currently open access. It has received 164 citations till now. The article focuses on the topics: Minimal residual disease & Hazard ratio.read more
Citations
More filters
Journal ArticleDOI
Standardized next-generation sequencing of immunoglobulin and T-cell receptor gene recombinations for MRD marker identification in acute lymphoblastic leukaemia; a EuroClonality-NGS validation study
Monika Brüggemann,Michaela Kotrova,Henrik Knecht,Jack Bartram,Myriam Boudjogrha,Vojtech Bystry,Grazia Fazio,Eva Froňková,Mathieu Giraud,Andrea Grioni,Jeremy Hancock,Dietrich Herrmann,Cristina Jimenez,Adam Krejci,John Moppett,Tomáš Reigl,Mikaël Salson,Blanca Scheijen,Martin Schwarz,Simona Songia,Michael Svaton,Jacques J.M. van Dongen,Patrick Villarese,Stephanie Wakeman,Gary Wright,Giovanni Cazzaniga,Frederic Davi,Ramón García-Sanz,David Gonzalez,Patricia J. T. A. Groenen,Michael Hummel,Elizabeth Macintyre,Kostas Stamatopoulos,Christiane Pott,Jan Trka,Nikos Darzentas,Anton W. Langerak +36 more
TL;DR: These validated and reproducible quality-controlled EuroClonality-NGS assays can be used for standardized NGS-based identification of IG/TR markers in lymphoid malignancies.
Journal ArticleDOI
Measurable residual disease detection by high-throughput sequencing improves risk stratification for pediatric B-ALL
Brent L. Wood,David Wu,Beryl Crossley,Yunfeng Dai,David Williamson,Charles Gawad,Michael J. Borowitz,Meenakshi Devidas,Kelly W. Maloney,Eric Larsen,Naomi J. Winick,Elizabeth A. Raetz,William L. Carroll,Stephen P. Hunger,Mignon L. Loh,Harlan Robins,Ilan R. Kirsch +16 more
TL;DR: The higher analytic sensitivity and lower false-negative rate of HTS improves upon FC for MRD detection in pediatric B-ALL by identifying a novel subset of patients at end of induction who are essentially cured using current chemotherapy and identifying MRD at 0.01% in up to one-third of patients who are missed at the same threshold by FC.
Journal ArticleDOI
Effect of Postreinduction Therapy Consolidation With Blinatumomab vs Chemotherapy on Disease-Free Survival in Children, Adolescents, and Young Adults With First Relapse of B-Cell Acute Lymphoblastic Leukemia: A Randomized Clinical Trial
Patrick A. Brown,Lingyun Ji,Xinxin Xu,Meenakshi Devidas,Laura E. Hogan,Michael J. Borowitz,Elizabeth A. Raetz,Gerhard Zugmaier,Elad Sharon,Melanie Brooke Bernhardt,Stephanie A. Terezakis,Lia Gore,James A. Whitlock,Michael A. Pulsipher,Stephen P. Hunger,Mignon L. Loh +15 more
TL;DR: In this article, a randomized phase 3 clinical trial was conducted by the Children's Oncology Group at 155 hospitals in the US, Canada, Australia, and New Zealand with enrollment from December 2014 to September 2019 and follow-up until September 30, 2020.
Journal ArticleDOI
CAR-T Cell Therapy for Acute Lymphoblastic Leukemia: Transforming the Treatment of Relapsed and Refractory Disease
TL;DR: CAR-T cells are a feasible, effective, and rapidly evolving therapy for patients with relapsed and refractory B cell malignancies.
Journal ArticleDOI
The consensus on the monitoring, treatment, and prevention of leukemia relapse after allogeneic hematopoietic stem cell transplantation in China.
Yu Wang,Hu Chen,Jing Chen,Mingzhe Han,Jianda Hu,Jiong Hu,He Huang,Yongrong Lai,Dai-Hong Liu,Qifa Liu,Ting Liu,Ming Jiang,Hanyun Ren,Yongping Song,Zimin Sun,Chun Wang,Jianmin Wang,Depei Wu,Kailin Xu,Xi Zhang,Lan-Ping Xu,Kai-Yan Liu,Xiao-Jun Huang,Xiao-Jun Huang +23 more
TL;DR: The consensus on routine practices of post-HSCT relapse management in China is summarized and focused on the recommendations of MRD monitoring, risk stratification directed strategies, and modified DLI system.
References
More filters
Journal ArticleDOI
Graft-versus-leukemia reactions after bone marrow transplantation
Mary M. Horowitz,Robert Peter Gale,Paul M. Sondel,John M. Goldman,J. H. Kersey,HJ Kolb,A. A. Rimm,O Ringden,C. Rozman,Bruno Speck +9 more
TL;DR: The results explain the efficacy of allogeneic bone marrow transplantation in eradicating leukemia, provide evidence for a role of the immune system in controlling human cancers, and suggest future directions to improve leukemia therapy.
An Empirical Transition Matrix for Non-homogeneous Markov Chains Based on Censored Observations
TL;DR: In this article, a product limit estimator for the transition probabilities of a non-homogeneous Markov chain with finitely many states is proposed, expressed as a product integral and its properties are studied by means of the theory of square integrable martingales.
Journal ArticleDOI
Clinical significance of minimal residual disease in childhood acute lymphoblastic leukemia and its relationship to other prognostic factors: a Children's Oncology Group study.
Michael J. Borowitz,Meenakshi Devidas,Stephen P. Hunger,W. Paul Bowman,W. Paul Bowman,Andrew J. Carroll,William L. Carroll,Stephen B. Linda,Paul L. Martin,D. Jeanette Pullen,David S. Viswanatha,Cheryl L. Willman,Naomi J. Winick,Bruce M. Camitta +13 more
TL;DR: Day-29 marrow MRD was the most important prognostic variable in multi-variate analysis and associated with shorter event-free survival (EFS) in all risk groups; even patients with 0.1% day-29 MRD had poor outcome compared with patients negative for MRD patients.
Journal ArticleDOI
Molecular response to treatment redefines all prognostic factors in children and adolescents with B-cell precursor acute lymphoblastic leukemia: results in 3184 patients of the AIEOP-BFM ALL 2000 study
Valentino Conter,Claus R. Bartram,Maria Grazia Valsecchi,André Schrauder,Renate Panzer-Grümayer,Anja Möricke,Maurizio Aricò,Martin Zimmermann,Georg Mann,Giulio Rossi,Martin Stanulla,Franco Locatelli,Giuseppe Basso,Felix Niggli,Elena Barisone,Guenter Henze,Wolf-Dieter Ludwig,Oskar A. Haas,Giovanni Cazzaniga,Rolf Koehler,Daniela Silvestri,Jutta Bradtke,Rosanna Parasole,Rita Beier,Jacques J.M. van Dongen,Andrea Biondi,Martin Schrappe +26 more
TL;DR: Standardized quantitative assessment of minimal residual disease based on immunoglobulin and T-cell receptor gene rearrangements as polymerase chain reaction targets (PCR-MRD) at 2 time points (TPs) is introduced, to stratify patients in a large prospective study.
Journal ArticleDOI
Using synthetic templates to design an unbiased multiplex PCR assay
Christopher S. Carlson,Ryan O. Emerson,Anna Sherwood,Cindy Desmarais,Moon Chung,Joseph M. Parsons,Michelle S. Steen,Marissa A. LaMadrid-Herrmannsfeldt,David Williamson,Robert J. Livingston,David Wu,Brent L. Wood,Mark J. Rieder,Harlan Robins +13 more
TL;DR: A multiplex PCR with a mixture of primers targeting the rearranged variable and joining segments to capture receptor diversity is applied to a multiplex T cell receptor gamma sequencing assay and can be extended to any adaptive immune locus.
Related Papers (5)
Analysis of minimal residual disease by Ig/TCR gene rearrangements: guidelines for interpretation of real-time quantitative PCR data.
V H J van der Velden,Giovanni Cazzaniga,André Schrauder,Jeremy Hancock,Peter Bader,E R Panzer-Grümayer,Thomas Flohr,Rosemary Sutton,Hélène Cavé,Hans O. Madsen,J M Cayuela,Jan Trka,Cornelia Eckert,Letizia Foroni,U zur Stadt,Kheira Beldjord,Thorsten Raff,C. E. Van Der Schoot,J. J. M. Van Dongen +18 more
Prognostic value of minimal residual disease in acute lymphoblastic leukaemia in childhood
Jacques J.M. van Dongen,T Seriu,E. Renate Panzer-Grümayer,Andrea Biondi,M. J. Pongers-Willemse,Lilly Corral,Frank Stolz,Martin Schrappe,Giuseppe Masera,Willem Kamps,Helmuth Gadner,Elisabeth R. van Wering,Wolf-Dieter Ludwig,Giuseppe Basso,Marianne Ac de Bruijn,Giovanni Cazzaniga,Klaudia Hettinger,Anna van der Does-van den Berg,Wim C. J. Hop,Hansjörg Riehm,Claus R. Bartram +20 more