IL-12-Deficient Mice Are Defective in IFNγ Production and Type 1 Cytokine Responses
Jeanne Magram,Suzanne E. Connaughton,Rajeev R. Warrier,Daisy Carvajal,Chang-You Wu,Jessica Ferrante,Colin L. Stewart,Ulla Sarmiento,Denise A. Faherty,Maurice K. Gately +9 more
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TLDR
It is indicated that IL-12 plays an essential role in regulating IFNγ production and in facilitating normal DTH responses and other phenomena associated with Th1 responses and cell-mediated immunity, i.e., IL-2 secretion and CTL generation, were not compromised in the absence of IL- 12.About:
This article is published in Immunity.The article was published on 1996-05-01 and is currently open access. It has received 984 citations till now. The article focuses on the topics: Interleukin 12 & CTL*.read more
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Interleukin 17–producing CD4 + effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages
Laurie E. Harrington,Robin D. Hatton,Paul R. Mangan,Henrietta Turner,Theresa L. Murphy,Kenneth M. Murphy,Casey T. Weaver +6 more
TL;DR: Findings provide a basis for understanding how inhibition of IFN-γ signaling enhances development of pathogenic TH-17 effector cells that can exacerbate autoimmunity.
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Functional diversity of helper T lymphocytes.
TL;DR: The existence of subsets of CD4+ helper T lymphocytes that differ in their cytokine secretion patterns and effector functions provides a framework for understanding the heterogeneity of normal and pathological immune responses.
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The Transcription Factor GATA-3 Is Necessary and Sufficient for Th2 Cytokine Gene Expression in CD4 T Cells
TL;DR: In transgenic mice, elevated GATA-3 in CD4 T cells caused Th2 cytokine gene expression in developing Th1 cells, indicating that Gata-3 is necessary and sufficient for Th2inflammatory gene expression.
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Cytokines Induce the Development of Functionally Heterogeneous T Helper Cell Subsets
TL;DR: I would like to thank Bob Coffman, Thierry von der Weid, Nancy Hosken, Amy Beebe, Steve Hurst, and Douglas Robinson for useful suggestions and discussion and Lewis Lanier for critical reviewing of the mansucript.
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THE INTERLEUKIN-12/INTERLEUKIN-12-RECEPTOR SYSTEM: Role in Normal and Pathologic Immune Responses
Maurice K. Gately,Louis M. Renzetti,Jeanne Magram,Alvin S. Stern,Luciano Adorini,Ueli Gubler,David H. Presky +6 more
TL;DR: Inhibition of IL-12 synthesis or activity may be beneficial in diseases associated with pathologic Th1 responses, such as multiple sclerosis or Crohn's disease, and administration of recombinant IL- 12 may have utility in the treatment of diseasesassociated with pathological Th2 responses such as allergic disorders and asthma.
References
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Development of TH1 CD4+ T cells through IL-12 produced by Listeria-induced macrophages
Chyi-Song Hsieh,Steven E. Macatonia,Catherine S. Tripp,Stanley F. Wolf,Anne O'Garra,Kenneth M. Murphy +5 more
TL;DR: This regulatory pathway may have evolved to enable innate immune cells, through interactions with microbial pathogens, to direct development of specific immunity toward the appropriate TH1 phenotype.
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Cloning of a new cytokine that induces IFN-gamma production by T cells.
Haruki Okamura,H Tsutsi,T Komatsu,M Yutsudo,A Hakura,T Tanimoto,K Torigoe,T Okura,Y Nukada,K Hattori +9 more
TL;DR: The cloning of a recently identified IFN-γ-inducing factor (IGIF) that augments natural killer activity in spleen cells and may be involved in the development of Thl cells and also in mechanisms of tissue injury in inflammatory reactions is reported.
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Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in mice
TL;DR: It is demonstrated that src is not required for general cell viability (possibly because of functional overlap with other tyrosine kinases related to src) and an essential role for src in bone formation is uncovered.
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Identification and purification of natural killer cell stimulatory factor (NKSF), a cytokine with multiple biologic effects on human lymphocytes.
M Kobayashi,Lori Fitz,M Ryan,Rodney M. Hewick,Steven C. Clark,S Chan,R Loudon,F Sherman,B Perussia,Giorgio Trinchieri +9 more
TL;DR: Data strongly suggest that the same molecule mediates these three activities, although the presence of traces of contaminant peptides even in the most purified NKSF preparations does not allow us to exclude the possibility that distinct biologically active molecules have been co-purified.