IL-17 and Th17 Cells.
Citations
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Cites background from "IL-17 and Th17 Cells."
...These Th17 cells secrete members of the IL-17 proinflammatory cytokine family, especially IL-17A and IL-17F (Korn et al., 2009), and play a key role in infection by pathogens and in gut immunity (see Review by D.R. Littman and A.Y. Rudensky on page 845 of this issue)....
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...These Th17 cells secrete members of the IL-17 proinflammatory cytokine family, especially IL-17A and IL-17F (Korn et al., 2009), and play a key role in infection by pathogens and in gut immunity (see Review by D....
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...Th17 cells also secrete IL-21, which induces activation of Th17 cells in an autocrine manner (Korn et al., 2009)....
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2,615 citations
Cites background from "IL-17 and Th17 Cells."
...It has been shown that IL-6, in combination with transforming growth factor (TGF)-b, is indispensable for Th17 differentiation from naı̈ve CD4þ T cells (Korn et al. 2009), but that IL-6 also inhibits TGF-b-induced Treg differentiation (Bettelli et al....
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...It has been shown that IL-6, in combination with transforming growth factor (TGF)-b, is indispensable for Th17 differentiation from naı̈ve CD4þ T cells (Korn et al. 2009), but that IL-6 also inhibits TGF-b-induced Treg differentiation (Bettelli et al. 2006)....
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References
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"IL-17 and Th17 Cells." refers background in this paper
...In addition, TGF-β induces the Treg-specific transcription factor Foxp3, which is required for the induction and maintenance of induced Treg cells (iTreg) in the peripheral immune compartment (64, 65)....
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4,616 citations
"IL-17 and Th17 Cells." refers background in this paper
...Furthermore, transduction of naive T cells with a retroviral vector containing RORγt induces the development of IL17-producing T cells (10)....
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...The steroid receptor–type nuclear receptor RORγt, which is a splice variant of RORγ expressed in T cells (56, 57), is selectively expressed in in vitro–differentiated Th17 cells and in IL-17+ T cells present in the lamina propria of naive mice (10)....
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...In the past five years, we have witnessed an accumulation of information on this new T cell subset: The cytokines for its differentiation and expansion have been identified (2–9) and the key transcription factors that are involved in its generation have been elucidated (10, 11), firmly establishing Th17 cells as an independent T helper cell lineage in human and mouse....
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...RORγt appears to be required for IL-17 production, as mice reconstituted with the bone marrow of RORγtdeficient mice show an impaired Th17 differentiation (10)....
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4,616 citations
"IL-17 and Th17 Cells." refers background in this paper
...On the basis of this and other studies, investigators proposed that IL-17-producing T cells are a distinct T helper cell subset, which was named Th17 cells (9, 18, 19)....
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