IL-17 in synovial fluids from patients with rheumatoid arthritis is a potent stimulator of osteoclastogenesis
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Cites background from "IL-17 in synovial fluids from patie..."
...Although cytokines, such as tumour necrosis factor (TNF)α, interleukin (IL)-1, IL-11 and IL-1...
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References
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"IL-17 in synovial fluids from patie..." refers background or methods in this paper
...Treatment of osteoblasts with 1α ,25(OH)2D3, PTH, PGE2, or IL-11 upregulates ODF mRNA expression (18)....
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...A higher concentration (at 5 µg/mL) of IL-17 antibody, however, did not inhibit the OCL formation induced by 1α,25(OH)2D3, PTH, or IL-1....
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...Discussion Recent evidence indicates that ODF, a ligand for OCIF, is expressed as a membrane-associated protein in osteoblasts/stromal cells and that it stimulates murine and human OCL formation in the absence of osteoblasts/stromal cells (18, 21, 38)....
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...Similarly, coculture experiments using VDR knockout mice and PTH/PTHrP receptor knockout mice have indicated that the signals mediated by 1α,25(OH)2D3 and PTH, respectively, are also transduced into osteoblasts/stromal cells, but not into osteoclast precursors, to induce osteoclast formation (11, 12)....
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...These boneresorbing factors were classified into 3 categories according to their signal transduction pathways: (a) 1α,25-dihydroxyvitamin D3 [1α,25(OH)2D3] induced OCL formation via 1α,25(OH)2D3 receptors (VDR) present in the nuclei; (b) parathyroid hormone (PTH), PTH-related protein (PTHrP), prostaglandin E2 (PGE2), and IL-1 induced OCL formation via the A kinase system; and (c) IL-11, oncostatin M, leukemia inhibitory factor, and IL-6 in the presence of soluble IL-6 receptors, all of which transduce their signals through a signal-transducing gp130 protein, also induced OCL formation in vitro....
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5,050 citations
"IL-17 in synovial fluids from patie..." refers background or methods in this paper
...Treatment of osteoblasts with 1α ,25(OH)2D3, PTH, PGE2, or IL-11 upregulates ODF mRNA expression (18)....
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...A higher concentration (at 5 µg/mL) of IL-17 antibody, however, did not inhibit the OCL formation induced by 1α,25(OH)2D3, PTH, or IL-1....
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...ODF was a ligand of OCIF and was found to be identical to TRANCE/ RANKL/OPGL (18–21)....
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...OCIF/OPG/TR1 was a secreted member of the TNF receptor family and inhibited osteoclast differentiation by preventing cell-cell interaction between osteoclast progenitors and bone marrow–derived stromal cells (13–15, 17)....
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...OCIF was identical to osteoprotegerin (OPG) (14, 15) and TR1 (16, 17)....
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4,098 citations
2,306 citations
"IL-17 in synovial fluids from patie..." refers methods in this paper
...Treatment of osteoblasts with 1α ,25(OH)2D3, PTH, PGE2, or IL-11 upregulates ODF mRNA expression (18)....
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...A higher concentration (at 5 µg/mL) of IL-17 antibody, however, did not inhibit the OCL formation induced by 1α,25(OH)2D3, PTH, or IL-1....
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...Similarly, coculture experiments using VDR knockout mice and PTH/PTHrP receptor knockout mice have indicated that the signals mediated by 1α,25(OH)2D3 and PTH, respectively, are also transduced into osteoblasts/stromal cells, but not into osteoclast precursors, to induce osteoclast formation (11, 12)....
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...These boneresorbing factors were classified into 3 categories according to their signal transduction pathways: (a) 1α,25-dihydroxyvitamin D3 [1α,25(OH)2D3] induced OCL formation via 1α,25(OH)2D3 receptors (VDR) present in the nuclei; (b) parathyroid hormone (PTH), PTH-related protein (PTHrP), prostaglandin E2 (PGE2), and IL-1 induced OCL formation via the A kinase system; and (c) IL-11, oncostatin M, leukemia inhibitory factor, and IL-6 in the presence of soluble IL-6 receptors, all of which transduce their signals through a signal-transducing gp130 protein, also induced OCL formation in vitro....
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...Synthetic human PTH(1-34) was provided by Asahi Chemical Industry (Tokyo, Japan)....
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1,576 citations
"IL-17 in synovial fluids from patie..." refers background or methods in this paper
...(32) reported that IL-17 stimulated epithelial, endothelial, and fibroblastic stromal cells to secrete several cytokines, including IL-6, IL-8, GCSF, and PGE2....
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...Treatment of osteoblasts with 1α ,25(OH)2D3, PTH, PGE2, or IL-11 upregulates ODF mRNA expression (18)....
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...A higher concentration (at 5 µg/mL) of IL-17 antibody, however, did not inhibit the OCL formation induced by 1α,25(OH)2D3, PTH, or IL-1....
[...]
...Similarly, coculture experiments using VDR knockout mice and PTH/PTHrP receptor knockout mice have indicated that the signals mediated by 1α,25(OH)2D3 and PTH, respectively, are also transduced into osteoblasts/stromal cells, but not into osteoclast precursors, to induce osteoclast formation (11, 12)....
[...]
...These boneresorbing factors were classified into 3 categories according to their signal transduction pathways: (a) 1α,25-dihydroxyvitamin D3 [1α,25(OH)2D3] induced OCL formation via 1α,25(OH)2D3 receptors (VDR) present in the nuclei; (b) parathyroid hormone (PTH), PTH-related protein (PTHrP), prostaglandin E2 (PGE2), and IL-1 induced OCL formation via the A kinase system; and (c) IL-11, oncostatin M, leukemia inhibitory factor, and IL-6 in the presence of soluble IL-6 receptors, all of which transduce their signals through a signal-transducing gp130 protein, also induced OCL formation in vitro....
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