Image quality and data quantification in dopamine transporter SPECT: advantage of 3-dimensional OSEM reconstruction?
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...Transverse reconstructed slices were generated as previously reported [40]....
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...The position and rotation of VOI were manually adjusted to the individual’s anatomy without changing the VOI size, as described previously.(36) A semiquantitative assessment of the regional BPND (BPND = mean ROI counts/mean occipital counts j 1)(22) was performed with bilateral occipital cortex as a reference region devoid of specific binding....
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References
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"Image quality and data quantificati..." refers methods in this paper
...BPND is the primary outcome measure of DAT SPECT studies, which is proportional to the density of striatal DAT available for 123 I-FP-CIT binding.(7) FIGURE 1....
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277 citations
"Image quality and data quantificati..." refers methods in this paper
...Imaging and quantification of presynaptic dopamine transporters (DATs) availability with SPECT and ligands like N-(3-fluoropropyl)2A-carbomethoxy-3A-(4-iodophenyl)nortropane ((123)I-FP-CIT) is an important tool for the diagnosis and follow-up of neurodegenerative parkinsonian syndromes and dementia with Lewy bodies.(1) The commonly used reconstruction method for (123)I-FP-CIT SPECT is filtered back projection (FBP)....
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"Image quality and data quantificati..." refers result in this paper
...…approximately 100 EM-equivalent iterations (96; ie, 6 iterations with 16 subsets in the present example), in line with the recent phantom study by Dickson et al.10 The variability of counts in the occipital cortex, in turn, increases almost linearly with the number of EM-equivalent iterations…...
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...Furthermore, whereas 3D-OSEM was performed with recovery correction, this was not the case for 2D-OSEM, which explains that the increase in counts and BPND was considerably larger for 3D-OSEM than 2D-OSEM....
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...1A), BPND (given here for caudate nucleus) shows a saturation-like behavior with an increasing number of EM-equivalent iterations (=number of iterations number of subsets in case of 2D/3D-OSEM), being close to convergence at approximately 100 EM-equivalent iterations (96; ie, 6 iterations with 16 subsets in the present example), in line with the recent phantom study by Dickson et al.10 The variability of counts in the occipital cortex, in turn, increases almost linearly with the number of EM-equivalent iterations (Fig....
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...1A), BPND (given here for caudate nucleus) shows a saturation-like behavior with an increasing number of EM-equivalent iterations (=number of iterations number of subsets in case of 2D/3D-OSEM), being close to convergence at approximately 100 EM-equivalent iterations (96; ie, 6 iterations with 16 subsets in the present example), in line with the recent phantom study by Dickson et al.(10) The variability of counts in the occipital cortex, in turn, increases almost linearly with the number of EM-equivalent iterations (Fig....
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...1).10 Furthermore, Dickson et al10 showed in their phantom study that the same 2D-OSEMRM algorithm performed with 200 EM-equivalent iterations gave 4% to 17% higher BPND estimates than FBP did....
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57 citations
"Image quality and data quantificati..." refers methods in this paper
...In turn, several iterative reconstruction methods that can incorporate models of the physical aspects of SPECT imaging (eg, resolution, collimator, scatter radiation, and attenuation) have been proposed, facilitating improved image quality, most notably ordered-subset expectation maximization (OSEM) reconstruction with 3-dimensional (3D) resolution recovery.(2) In the present work, we contemplated an OSEM method that uses a measured 3D beam model for collimation for image reconstruction, which is performed simultaneously for all slices (3D-OSEM; Flash 3D Technology; Siemens, Erlangen, Germany)....
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53 citations
"Image quality and data quantificati..." refers methods in this paper
...Three-dimensional OSEM was shown to effectively minimize data deformation in the z direction and to improve SPECT image quality compared with conventional 2-dimensional (2D) OSEM.3 In addition, 3D-OSEM was found to be superior to FBP in image noise for low count statistics.4 Consequently, an improved image quality may be yielded even with a considerably reduced (approximately j50...
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...Furthermore, whereas 3D-OSEM was performed with recovery correction, this was not the case for 2D-OSEM, which explains that the increase in counts and BPND was considerably larger for 3D-OSEM than 2D-OSEM....
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...However, as a unique feature, 3D-OSEM reconstructs all slices simultaneously and models the collimator beams at all depths, which provides isotropic spatial resolution and minimizes localization errors and shape distortions in comparison to 2D-OSEM.3 Regression analyses revealed an excellent correlation between FBPlow and all other methods (R 2 Q 0.97)....
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...Thus, the present study was undertaken to investigate possible benefits of 3D-OSEM reconstruction for DAT SPECT imaging in image quality and data quantification in comparison to standard FBP and 2DOSEM....
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...%) injected activity dose and/or acquisition time.5,6 These features may be a particular advantage of 3D-OSEM in DAT or dopamine receptor SPECT studies: These studies are usually quantified by pseudo or peak equilibrium analyses, in which the estimate of binding site density (binding potential, BPND) 7 is calculated by the ratio of specific striatal ligand uptake to nonspecific ligand uptake in a reference region.8 Thus, an improved delineation of high-uptake striatal structures with enhanced signal recovery and an optimal image reconstruction of the low-uptake reference region may be provided by 3D-OSEM....
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