Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound-B.
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8,448 citations
Cites background or result from "Imaging brain amyloid in Alzheimer'..."
...Recently, molecular imaging methods able to measure AD pathology (Klunk et al. 2004) have revealed an even more surprising link to the default network: pathology preferentially accumulates in the default network even before symptoms emerge....
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...” Maps of Aß plaques in living individuals provide the key evidence (Klunk et al. 2004), as images of Aß plaques taken at the earliest stages of AD show a distribution that is remarkably similar to the anatomy of the default network (Buckner et al....
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...Maps of Aß plaques in living individuals provide the key evidence (Klunk et al. 2004), as images of Aß plaques taken at the earliest stages of AD show a distribution that is remarkably similar to the anatomy of the default network (Buckner et al. 2005, FIG....
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5,126 citations
Cites background from "Imaging brain amyloid in Alzheimer'..."
...Biomarkers of Ab plaques (labeled “A”) are cortical amyloid PET ligand binding [76,77] or low CSF Ab42 [78–80]....
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3,953 citations
3,951 citations
3,824 citations
References
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"Imaging brain amyloid in Alzheimer'..." refers methods in this paper
...F-fluorodeoxyglucose Analysis Parametric maps of glucose metabolic rate (rCMRglc) were generated by the Patlak technique using the time course of the tracer in arterialized-venous plasma as the input function.(22,23) Taking advantage of the 20-minute half-life of carbon 11, (18)FDG scans could be performed 120 minutes after the injection of PIB....
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2,576 citations
"Imaging brain amyloid in Alzheimer'..." refers background or result in this paper
...This pattern is very consistent with that described in postmortem studies of amyloid deposition in AD brain.(25,26) PIB images from HC subjects showed little or no PIB retention in cortical areas, leaving the subcortical white matter regions highest in relative terms....
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...The coupling between increased PIB retention and decreased (18)FDG metabolism was not an unexpected finding, given the well-known decrease in temporoparietal metabolism in AD patients(31) and the presence of extensive amyloid deposition in these same areas.(25,26) PET with (18)FDG and PIB might be considered as complementary methods, one looking directly at amyloid pathology and the other looking at metabolic dysfunction at the synapse that may or may not be related to the local pathology....
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...tex as a brain area very high in amyloid deposition but have not identified it as the site of greatest deposition.(25,26) This raises the question of whether the observation of highest PIB retention in the frontal cortex is real or an artefact....
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...In general, this pattern of PIB retention is consistent with the pattern of amyloid plaque deposition described in postmortem studies of AD brain.(25,26) These postmortem studies showed that, from the earliest stages, amyloid plaque deposition was distributed fairly evenly across neocortical association cortices in AD....
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1,623 citations