Journal ArticleDOI
Imaging exosome transfer from breast cancer cells to stroma at metastatic sites in orthotopic nude-mouse models.
Atsushi Suetsugu,Kimi Honma,Shigetoyo Saji,Hisataka Moriwaki,Takahiro Ochiya,Robert M. Hoffman +5 more
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TLDR
The results suggest that tumor-derived exosomes may contribute to forming a niche to promote tumor growth and metastasis.About:
This article is published in Advanced Drug Delivery Reviews.The article was published on 2013-03-01. It has received 265 citations till now. The article focuses on the topics: Exosome & Metastasis.read more
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Extracellular Vesicles in Cancer: Cell-to-Cell Mediators of Metastasis
Annette Becker,Basant Kumar Thakur,Joshua Mitchell Weiss,Han Sang Kim,Han Sang Kim,Héctor Peinado,David Lyden +6 more
TL;DR: Clinically, EVs may be biomarkers and novel therapeutic targets for cancer progression, particularly for predicting and preventing future metastatic development.
Journal ArticleDOI
Microenvironment-induced PTEN loss by exosomal microRNA primes brain metastasis outgrowth
Lin Zhang,Siyuan Zhang,Siyuan Zhang,Jun Yao,Frank J. Lowery,Qingling Zhang,Wen Chien Huang,Ping Li,Min Li,Xiao Wang,Chenyu Zhang,Hai Wang,Kenneth Ellis,Mujeeburahiman Cheerathodi,Joseph H. McCarty,Diane Palmieri,Jodi M. Saunus,Sunil R. Lakhani,Suyun Huang,Aysegul A. Sahin,Kenneth Aldape,Patricia S. Steeg,Dihua Yu +22 more
TL;DR: A remarkable plasticity of PTEN expression in metastatic tumour cells in response to different organ microenvironments is demonstrated, underpinning an essential role of co-evolution between the metastatic cells and their microenvironment during the adaptive metastatic outgrowth.
Journal ArticleDOI
Exosomes in cancer: small particle, big player
TL;DR: The multifaceted roles of exosomes, the small secreted particles, in communicating with other cells within tumor microenvironment are reviewed, suggesting they may provide promising biomarkers for cancer diagnosis and represent new targets for cancer therapy.
Journal ArticleDOI
MiR-133b promotes neural plasticity and functional recovery after treatment of stroke with multipotent mesenchymal stromal cells in rats via transfer of exosome-enriched extracellular particles
Hongqi Xin,Yi Li,Zhongwu Liu,Xinli Wang,Xia Shang,Yisheng Cui,Zheng Gang Zhang,Michael Chopp,Michael Chopp +8 more
TL;DR: The data suggest that exosomes from MSCs mediate the miR‐133b transfer to astrocytes and neurons, which regulate gene expression, subsequently benefit neurite remodeling and functional recovery after stroke.
Journal ArticleDOI
Visualization and tracking of tumour extracellular vesicle delivery and RNA translation using multiplexed reporters.
Charles P. Lai,Edward Y. Kim,Christian E. Badr,Ralph Weissleder,Thorsten R. Mempel,Bakhos A. Tannous,Xandra O. Breakefield +6 more
TL;DR: By multiplexing fluorescent and bioluminescent EV membrane reporters, this work reveals the rapid dynamics of both EV uptake and translation of EV-delivered cargo mRNAs in cancer cells that occurred within 1-hour post-horizontal transfer between cells.
References
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Journal ArticleDOI
Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells
TL;DR: It is shown that exosomes contain both mRNA and microRNA, which can be delivered to another cell, and can be functional in this new location, and it is proposed that this RNA is called “exosomal shuttle RNA” (esRNA).
Journal ArticleDOI
Prospective identification of tumorigenic breast cancer cells
Muhammad Al-Hajj,Max S. Wicha,Adalberto Benito-Hernandez,Sean J. Morrison,Sean J. Morrison,Michael F. Clarke +5 more
TL;DR: The ability to prospectively identify tumorigenic cancer cells will facilitate the elucidation of pathways that regulate their growth and survival and strategies designed to target this population may lead to more effective therapies.
Journal ArticleDOI
Circulating microRNAs as stable blood-based markers for cancer detection
Patrick S. Mitchell,Rachael K. Parkin,Evan M. Kroh,Brian R. Fritz,Brian R. Fritz,Stacia K. Wyman,Era L. Pogosova-Agadjanyan,Amelia Peterson,Jennifer Noteboom,Kathy O'Briant,April Allen,Daniel W. Lin,Daniel W. Lin,Daniel W. Lin,Nicole Urban,Charles W. Drescher,Beatrice S. Knudsen,Derek L. Stirewalt,Robert Gentleman,Robert L. Vessella,Robert L. Vessella,Peter S. Nelson,Daniel Martin,Daniel Martin,Muneesh Tewari +24 more
TL;DR: It is shown here that miRNAs are present in human plasma in a remarkably stable form that is protected from endogenous RNase activity and established the measurement of tumor-derived mi RNAs in serum or plasma as an important approach for the blood-based detection of human cancer.
Journal ArticleDOI
Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell
Dominique Bonnet,John E. Dick +1 more
TL;DR: It is demonstrated that the cell capable of initiating human AML in non-obese diabetic mice with severe combined immunodeficiency disease (NOD/SCID mice) — termed the SCID leukemia-initiating cell, or SL-IC — possesses the differentiate and proliferative capacities and the potential for self-renewal expected of a leukemic stem cell.
Journal ArticleDOI
Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers
Johan Skog,T. Wurdinger,van Rijn S,Dimphna H. Meijer,Gainche L,Miguel Sena-Esteves,William T. Curry,Bob S. Carter,Anna M. Krichevsky,Xandra O. Breakefield +9 more
TL;DR: Tumour-derived microvesicles may provide diagnostic information and aid in therapeutic decisions for cancer patients through a blood test by incorporating an mRNA for a reporter protein into them, and it is demonstrated that messages delivered by microvesicle are translated by recipient cells.
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