Book ChapterDOI
Imaging tumor microenvironment with ultrasound
Mallika Sridhar,Michael F. Insana +1 more
- Vol. 19, pp 516-528
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TLDR
In this article, the authors used ultrasound to image viscoelastic features of tumors, which describe microenvironmental factors that stimulate signaling pathways in tumors that ultimately affect metastatic potential and response to traditional therapeutics.Abstract:
Recent advances in molecular biology are providing new opportunities for breast cancer imaging. Our approach uses ultrasound to image viscoelastic features of tumors. These features describe microenvironmental factors that stimulate signaling pathways in tumors that ultimately affect metastatic potential and response to traditional therapeutics. This paper explains the motivation for the approach, describes measurements in phantoms and patients, and defines measurement sensitivity using hydrogels with tissue-like features.read more
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Journal ArticleDOI
Viscoelasticity imaging using ultrasound: parameters and error analysis.
TL;DR: The focus of this paper is on imaging parameter estimation from ultrasonic echo data, and how jitter from hand-held force applicators used for clinical applications propagate through the imaging chain to generate image noise.
Journal ArticleDOI
A Robust Method to Estimate the Time Constant of Elastographic Parameters
TL;DR: Variable projection (VP) is proposed, a new technique named variable projection to estimate accurately and robustly the TC and steady-state value of the elastographic parameter of interest from its temporal curve that is robust to noise and capable of estimating the time constant with accuracy higher than that of typically employed curve-fitting techniques.
Posted Content
A spline interpolation based data reconstruction technique for estimation of strain time constant in ultrasound poroelastography
TL;DR: A cubic spline–based interpolation method, which allows to use only good quality strain frames (i.e., frames with sufficiently high signal-to-noise ratio [SNR]) to estimate the strain TC, and is of great help in applications relying on the accurate assessment of the temporal behavior of strain data.
Journal ArticleDOI
A Spline Interpolation–based Data Reconstruction Technique for Estimation of Strain Time Constant in Ultrasound Poroelastography:
TL;DR: In this article, a cost-effective and non-invasive imaging technique, which can be used to reconstruct mechanical parameters of tissues such as Young's modulus, Poisson's ratio, inters...
Proceedings ArticleDOI
4J-1 Towards a Molecular Level Understanding of Elasticity in Tissues and Hydrogels
TL;DR: In this article, the authors used low order discrete rheological models from linear viscoelastic theory to reduce data dimensionality yielding parameters related to stiffness and viscosity: elastic strain and two retardation time constants.
References
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Journal ArticleDOI
In vivo breast tumor detection using transient elastography.
Jeremy Bercoff,S. Chaffai,Mickael Tanter,Laurent Sandrin,Stefan Catheline,Mathias Fink,Jean-Luc Gennisson,M. Meunier +7 more
TL;DR: The preliminary in vivo results demonstrate the clinical applicability of the transient elastography technique for breast lesion detection as well as the shear propagation imaging with an ultrafast echographic scanner able to reach frame rates up to 6000 Hz.
Journal ArticleDOI
Visualization and quantification of breast cancer biomechanical properties with magnetic resonance elastography.
TL;DR: It is shown that through the judicious choice of information from previous contrast-enhanced MRI breast images, MRE data acquisition requirements can be significantly reduced while maintaining robust modulus reconstruction in the presence of strain noise.
Journal Article
Increased content of Type V Collagen in desmoplasia of human breast carcinoma.
TL;DR: It is proposed that desmoplasia of human breast carcinoma manifests a characteristic collagen profile and that the increased Type V may be produced by specialized cells such as myofibroblasts in the interstitium, which are recruited in response to invasive carcinoma.
Journal ArticleDOI
Ultrasound elastography based on multiscale estimations of regularized displacement fields
TL;DR: Introducing a smoothness constraint into motion field estimation helped solve ambiguities due to incoherent motion, leading to elastograms less degraded by decorrelation noise than the ones obtained from correlation-based techniques.
Journal ArticleDOI
Testing the limitations of 2-D companding for strain imaging using phantoms
TL;DR: Examining the conditions that limit the effectiveness of 2-D local companding through a series of experiments using phantoms with tissue-like acoustic and elasticity properties found that strain noise remained relatively unchanged as the applied compression increased to 5% of the phantom height, while target contrast increased in proportion to the compression.