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Immuno-regenerative biomaterials for in situ cardiovascular tissue engineering - Do patient characteristics warrant precision engineering?

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TLDR
In this paper, the potential role of patient-specific parameters like sex, age, ethnicity, hemodynamics, and a multifactorial disease profile, with special emphasis on their contribution to the inflammation-driven processes of in situ tissue engineering, was investigated.
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This article is published in Advanced Drug Delivery Reviews.The article was published on 2021-11-01 and is currently open access. It has received 22 citations till now. The article focuses on the topics: Tissue engineering.

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Biocompatible Synthetic Polymers for Tissue Engineering Purposes.

TL;DR: The role of synthetic polymers in tissue engineering, their design and properties in relation to each type of application, and selected recent achievements of tissue engineering using synthetic polymer are outlined to provide insight into how they contribute to the advancement of the field in the near future as discussed by the authors .
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Inflammatory and regenerative processes in bioresorbable synthetic pulmonary valves up to two years in sheep-Spatiotemporal insights augmented by Raman microspectroscopy.

TL;DR: In this article, the authors used a comprehensive histology and immunohistochemistry with Raman micro-spectroscopy for the spatiotemporal analysis of in situ tissue-engineered pulmonary valves with follow-up to 24 months from a previous preclinical study in sheep.
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Animal studies for the evaluation of in situ tissue-engineered vascular grafts — a systematic review, evidence map, and meta-analysis

TL;DR: A literature search (PubMed, Embase) yielded 15,896 studies, of which 182 studies met the inclusion criteria (n = 5,101 animals) and Meta-analysis on graft patency with subgroup analysis for species, age, sex, implantation site and follow-up time demonstrated model-specific variations as mentioned in this paper .
Journal ArticleDOI

Animal studies for the evaluation of in situ tissue-engineered vascular grafts — a systematic review, evidence map, and meta-analysis

TL;DR: A literature search (PubMed, Embase) yielded 15,896 studies, of which 182 studies met the inclusion criteria (n = 5,101 animals) and Meta-analysis on graft patency with subgroup analysis for species, age, sex, implantation site and follow-up time demonstrated model-specific variations as mentioned in this paper .
Journal ArticleDOI

Macrophage-extracellular matrix interactions: Perspectives for tissue engineered heart valve remodeling

TL;DR: An overview of in situ tissue engineering approaches and their clinical relevance is provided, followed by a discussion on the fundamentals of the remodeling cascades, and the role of circulation-derived and resident tissue macrophages is focused on.
References
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Journal ArticleDOI

Exploring the full spectrum of macrophage activation.

TL;DR: This Review suggests a new grouping of macrophages based on three different homeostatic activities — host defence, wound healing and immune regulation, and proposes that similarly to primary colours, these three basic macrophage populations can blend into various other 'shades' of activation.
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Alternative activation of macrophages

TL;DR: The evidence in favour of alternative macrophage activation by the TH2-type cytokines interleukin-4 (IL-4) and IL-13 is assessed, and its limits and relevance to a range of immune and inflammatory conditions are defined.
Journal ArticleDOI

Global, regional, and national comparative risk assessment of 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks in 188 countries, 1990-2013: A systematic analysis for the Global Burden of Disease Study 2013

Mohammad H. Forouzanfar, +736 more
- 05 Dec 2015 - 
TL;DR: The Global Burden of Disease, Injuries, and Risk Factor study 2013 (GBD 2013) as discussed by the authors provides a timely opportunity to update the comparative risk assessment with new data for exposure, relative risks, and evidence on the appropriate counterfactual risk distribution.
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