Journal ArticleDOI
Immunobiology of zinc and zinc therapy.
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TLDR
It is found that zinc levels higher than 0.5 mm – equivalent to a daily dose of ∼45 mg zinc salt – had a toxic effect on immune cells, and the effect of long-term, low-dose zinc supplementation [zinc-hydrogenaspartate; UNIZINK 50 three times daily] is virtually nontoxic in adults.About:
This article is published in Immunology Today.The article was published on 1999-02-01. It has received 15 citations till now. The article focuses on the topics: Zinc deficiency & Zinc.read more
Citations
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Journal ArticleDOI
Zinc-Altered Immune Function
Klaus-Helge Ibs,Lothar Rink +1 more
TL;DR: Impaired immune functions due to zinc deficiency are shown to be reversed by an adequate zinc supplementation, which must be adapted to the actual requirements of the patient.
Journal ArticleDOI
Zinc and the immune system
Lothar Rink,P Gabriel +1 more
TL;DR: The relationship between Zn and the immune system is complex, since there are four different types of influence associated with Zn: dietary intake and the resorption of Zn depends on the composition of the diet and also on age and disease status.
Zinc and immune system.
TL;DR: The relationship between Zn and the immune system is complex, since there are four different types of influence associated with Zn, which influence the function of immunostimulants used in the experimental systems and the therapeutic use of Zn will be discussed in detail.
Book ChapterDOI
Extracellular and immunological actions of zinc.
Lothar Rink,Philip Gabriel +1 more
TL;DR: This review discusses the activity of extracellular zinc in in vitro cell systems, including keratinocytes, osteocytes and leukocytes, and the concentrations of zinc needed for a specific cell response.
Journal ArticleDOI
Zinc homeostasis and immunosenescence.
Martina Maywald,Lothar Rink +1 more
TL;DR: An impaired function of innate immune cells indicate a predominance of zinc deficiency in the elderly that may contribute to immunosenescence, and current findings about zinc deficiency and supplementation in elderly individuals are summarized.
References
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Journal ArticleDOI
Excessive intake of zinc impairs immune responses.
TL;DR: The effect of administration of large amounts of zinc on immune response and serum lipoproteins was examined and zinc supplementation with resultant excessive intake could have deleterious effects in healthy persons.
Journal ArticleDOI
The immunobiology of zinc
TL;DR: Zinc is required for range of immune functions, including T-cell activity, and its roles are reviewed and the implications for its therapeutic use are discussed.
Journal ArticleDOI
Effects of one year of supplementation with zinc and other micronutrients on cellular immunity in the elderly.
John D. Bogden,James M. Oleske,Marvin A. Lavenhar,Elizabeth M. Munves,Francis W. Kemp,K.S. Bruening,K. Holding,Thomas N. Denny,Michael A. Guarino,Bart Holland +9 more
TL;DR: Although plasma Zn increased significantly in the 100 mg Zn treatment group, concentrations of Zn in erythrocytes, mononuclear cells, polymorphonuclear leukocytes, and platelets were not significantly increased by zinc supplementation.