Immunogenicity of necrotic cell death
Citations
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Cites background from "Immunogenicity of necrotic cell dea..."
...Thus, it would be favorable to use and develop PSs which predominantly cause ICD in cancer cells for future approaches....
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...In a very recent work Garg et al. found elevated levels of Th1 and Th17 cells in the brain immune contexture of mice treated with an immunogenic cell death (ICD)-based DC vaccine against high-grade glioma (HGG) and subsequently inoculated with the respective glioma cells....
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...In general, PDT is able to result in apoptosis, necrosis, the so-called immunogenic cell death (ICD), and autophagy....
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...Intensive research in the field of cell death in the following years led to the fairly new concept of ICD....
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...Importantly, so far hypericin is the only PS shown to induce all major molecular and immunological hallmarks of ICD....
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References
15,416 citations
"Immunogenicity of necrotic cell dea..." refers background in this paper
...It was proposed as a universal clearance mechanism of unwanted, aged, stressed cells from the body, quiescently, without induction of inflammation and injury [50]....
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...Apoptosis was considered to be a programmed and controlled type of cell death in physiology [50]....
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4,825 citations
"Immunogenicity of necrotic cell dea..." refers background in this paper
...the immune system against self-antigens [67]....
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...The ‘‘Danger theory’’, which was initially proposed by Polly Matzinger postulated that the immune system has an ability to recognize endogenous signals from stressed, injured dying/dead cells and responds to it [67]....
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4,108 citations
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