Immunoglobulin G4-Related Disease and the Lung
Citations
466 citations
51 citations
14 citations
13 citations
Cites background from "Immunoglobulin G4-Related Disease a..."
...Clinical symptoms observed in patients with IgG4-related lung disease are nonspecific and include cough, chest pain, and dyspnea (60)....
[...]
...Lungs (60) Solid nodular densities; round-shaped ground-glass opacities; thickening of the bronchovascular bundles and interlobular septa; alveolar interstitial type with bronchiectasis resembling interstitial lung disease and pleural thickening...
[...]
9 citations
References
2,355 citations
2,041 citations
"Immunoglobulin G4-Related Disease a..." refers background or methods in this paper
...Suggested cutoff values for quantitating IgG4(1) plasma cells in the diagnosis of IgG4-RD vary depending on the organ, according to the current consensus statement on pathologic analysis.(20) For the lung, greater than 20 or greater than 50 IgG4(1) plasma cells per high-power field in nonsurgical biopsy and surgical biopsy specimens,...
[...]
...Similarly, the density of IgG4(1) plasma cells in involved organs varies and influences the quantitative cutoff values used for number of IgG4(1) plasma cell per high-power field and IgG4(1)/IgG(1) cell ratio in the histopathologic diagnosis of IgG4-RD.(20,21)...
[...]
...Other laboratory abnormalities that may be observed in patients with IgG4-RD include mildto-moderate peripheral eosinophilia, elevated C-reactive protein level and erythrocyte sedimentation rate, polyclonal hypergammaglobulinemia, antinuclear autoantibodies, rheumatoid factor, and hypocomplementemia.(3,8,20,21,32) Recent studies have suggested that circulating plasmablast levels are elevated in patients with IgG4-RD and may correlate with disease activity....
[...]
...The respective cutoff values for the pleura are greater than 50 IgG4(1) plasma cells per high-power field and greater than 40% IgG4(1)/IgG(1) plasma cell ratio.(20) To identify the characteristic histopathologic features of IgG4-RD within the thorax, a surgical biopsy specimen is generally needed....
[...]
...histopathologic features, which should include dense lymphoplasmacytic infiltrates, a storiform pattern of fibrosis, and obliterative phlebitis combined with an increased number of IgG4(1) plasma cells (Box 2).(2,3,6,20,21) None of the histopathologic features or laboratory findings, including a high serum IgG4 level, is specific for the diagnosis of IgG4-RD....
[...]
1,948 citations
1,417 citations
834 citations
"Immunoglobulin G4-Related Disease a..." refers background in this paper
...histopathologic features, which should include dense lymphoplasmacytic infiltrates, a storiform pattern of fibrosis, and obliterative phlebitis combined with an increased number of IgG4(1) plasma cells (Box 2).(2,3,6,20,21) None of the histopathologic features or laboratory findings, including a high serum IgG4 level, is specific for the diagnosis of IgG4-RD....
[...]
...It has since become clear that IgG4-RD can cause an immune-mediated fibroinflammatory process, commonly manifesting as mass-like lesions, in various regions of the body including intrathoracic structures.(2,4,6,7) This pathologic process is characterized by infiltration of IgG4(1) plasma cells and a propensity to fibrosis leading to organ dysfunction....
[...]
Related Papers (5)
[...]