Immunology of COVID-19: Current State of the Science.
Citations
4,408 citations
2,933 citations
1,787 citations
1,345 citations
1,298 citations
References
36,578 citations
20,189 citations
16,635 citations
"Immunology of COVID-19: Current Sta..." refers background or result in this paper
...…(He et al., 2005), several current reports emphasize the occurrence of lymphopenia with drastically reduced numbers of both CD4 and CD8 T cells in moderate and severe COVID-19 cases (Figure 3) (Chen et al., 2020c; Nie et al., 2020b; Wang et al., 2020d; Zeng et al., 2020; Zheng et al., 2020b)....
[...]
...Of note, a SARS-CoV-1derived neutralizing antibody (47D11) (Wang et al., 2020a) and a single-chain antibody against SARS-CoV-2 (n3130) (Wu et al., 2020c) have also been shown to neutralize SARS-CoV-2 without inhibiting ACE2/RBD binding....
[...]
...Further, an inhibitor of host DHODH, a rate-limiting enzyme in pyrimidine synthesis, was able to inhibit SARS-CoV-2 growth in vitrowith greater efficacy than remdesivir or chloroquine (Wang et al., 2020e; Xiong et al., 2020)....
[...]
...IL-6 Associated with disease severity (hospitalization and ICU admission) and poor prognosis (Chen et al., 2020g; Huang et al., 2020b; Liu et al., 2020b, 2020f; Wang et al., 2020b)....
[...]
...However, there has been conflicting evidence whether CQ is more potent than HCQ in reducing viral load (Liu et al., 2020d; Wang et al., 2020b; Yao et al., 2020a)....
[...]
9,474 citations
7,493 citations
"Immunology of COVID-19: Current Sta..." refers background in this paper
...A growing body of evidence points to dysregulated myeloid responses that potentially drive the COVID-19 hallmark syndromes, such as acute respiratory distress syndrome (ARDS), cytokine release syndrome (CRS) and lymphopenia (Mehta et al., 2020)....
[...]
...Significantly elevated systemic levels of proinflammatory cytokine IL6 have been reported in several COVID-19 patient cohorts and shown to correlate with disease severity (Mehta et al., 2020)....
[...]