Immunomodulatory activities of common vegetables and spices of Umbelliferae and its related coumarins and flavonoids
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Cites background from "Immunomodulatory activities of comm..."
...Further, quercetin, rutin, and isoquercitrin were reported to have the immunomodulatory activities [69]....
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217 citations
Cites background from "Immunomodulatory activities of comm..."
...In addition there are a large number of other more complex compounds with the biological and the pharmacological properties of coumarin that have structures that are based on the coumarin nucleus [3-15]....
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...The diverse biological functions of coumarins include anti-leukemia [3-4], antiinflammation [5-6], anti-platelet aggregation [7-8], anti-cancer [9-10], anti-convulsant [11], comparative immunomodulatory [12], and analgesic [13-15] properties....
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...Among the three coumarins tested, two types of immunomodulation were exhibited and correlated with the number of methoxy groups including, a type 2 response of isopimpinellin (two methoxy group and lymphocyte activation), and a type 3 immunomodulation of bergapten and xanthotoxin (one methoxy group and elevation of IFN secretion), whereas the position of the methoxy group affected the immunomodulating potency such as bergapten (5-methoxypsoralen) and xanthotoxin (8-methoxypsoralen) [12]....
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