Journal ArticleDOI
Impact of anesthetic agents on cerebrovascular physiology in children.
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TLDR
The understanding of the effects of anesthetic agents on the physiology of cerebral vasculature in the pediatric population has significantly increased in the past decade allowing a more rationale decision making in anesthesia management.Abstract:
care to children with neurologic pathologies. The cerebral physiology is influenced by the developmental stage of the child. The understanding of the effects of anesthetic agents on the physiology of cerebral vasculature in the pediatric population has significantly increased in the past decade allowing a more rationale decision making in anesthesia management. Although no single anesthetic technique can be recommended, sound knowledge of the principles of cerebral physiology and anesthetic neuropharmacology will facilitate the care of pediatric neurosurgical patients.read more
Citations
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Journal ArticleDOI
Impact of sevoflurane anesthesia on cerebral blood flow in children younger than 2 years.
O. Rhondali,Aurélie Mahr,Sabine Simonin-Lansiaux,Mathilde De Queiroz,Khalid Rhzioual-Berrada,Sylvie Combet,Jean-Christophe Cejka,Dominique Chassard +7 more
TL;DR: To assess the impact of sevoflurane and anesthesia‐induced hypotension on cerebral blood flow (CBF) in children younger than 2 years, a large number of children were randomly assigned to the “good” or “bad” group.
Journal ArticleDOI
Impact of sevoflurane anesthesia on brain oxygenation in children younger than 2 years.
O. Rhondali,Simon Juhel,Sylvain Mathews,Quentin Cellier,François-Pierrick Desgranges,Aurélie Mahr,Mathilde De Queiroz,Agnès Pouyau,Khalid Rhzioual-Berrada,Dominique Chassard +9 more
TL;DR: To assess the impact of sevoflurane and anesthesia‐induced hypotension on brain oxygenation in children younger than 2 years, a large number of patients were referred to the neonatal intensive care unit.
Journal ArticleDOI
Brain temperature: heat production, elimination and clinical relevance.
TL;DR: The fundamental physiological principles of brain heat production, distribution and elimination under normal conditions are explained and why hypothermia cannot yet be recommended routinely in the management of children affected with various neurological insults are discussed.
Journal ArticleDOI
Anesthetic considerations for the pediatric oncology patient--part 2: systems-based approach to anesthesia.
TL;DR: This review presents a systems‐based approach to the impact from both tumor and its treatment in children, followed by a discussion of the relevant anesthetic considerations.
Book ChapterDOI
Basics and dynamics of neonatal and pediatric pharmacology.
TL;DR: A basic understanding of the developmental dynamics in pediatric pharmacology is also essential to delineating the future directions and priority areas of pediatric drug research and development.
References
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Journal ArticleDOI
Compartmental analysis of compliance and outflow resistance of the cerebrospinal fluid system
TL;DR: The distribution of compliance and outflow resistance between cerebral and spinal compartments was measured in anesthetized, ventilated cats by analysis of the cerebrospinal fluid (CSF) pressure response to changes in CSF volume.
Journal ArticleDOI
Impaired autoregulation of cerebral blood flow in the distressed newborn infant
TL;DR: Cerebral blood flow was measured, using the 133Xe clearance technique, a few hours after birth in 19 infants with varying degrees of respiratory distress syndrome, showing a linear relationship that was identical in infants with asphyxia at birth and infants with RDS only.
Journal ArticleDOI
Inhibition of Adrenal Steroidogenesis by the Anesthetic Etomidate
TL;DR: Physicians should be aware that etomidate inhibits adrenal steroidogenesis, and they should consider treating selected patients with corticosteroids if etamidate is used.
Journal ArticleDOI
Formation and absorption of cerebrospinal fluid in man.
Journal ArticleDOI
Effects of sevoflurane, propofol, and adjunct nitrous oxide on regional cerebral blood flow, oxygen consumption, and blood volume in humans
Kaike K. Kaisti,Jaakko Långsjö,Sargo Aalto,Vesa Oikonen,Hannu Sipilä,Mika Teräs,Susanna Hinkka,Liisa Metsähonkala,Harry Scheinin +8 more
TL;DR: The effects of sevoflurane and propofol as sole anesthetics and in combination with N2O on regional cerebral blood flow, metabolic rate of oxygen (rCMRO2), and blood volume (rCBV) in the living human brain using positron emission tomography are quantified.