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Journal ArticleDOI

Impact of anesthetic agents on cerebrovascular physiology in children.

Elöd Z. Szabó, +2 more
- 01 Feb 2009 - 
- Vol. 19, Iss: 2, pp 108-118
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TLDR
The understanding of the effects of anesthetic agents on the physiology of cerebral vasculature in the pediatric population has significantly increased in the past decade allowing a more rationale decision making in anesthesia management.
Abstract
care to children with neurologic pathologies. The cerebral physiology is influenced by the developmental stage of the child. The understanding of the effects of anesthetic agents on the physiology of cerebral vasculature in the pediatric population has significantly increased in the past decade allowing a more rationale decision making in anesthesia management. Although no single anesthetic technique can be recommended, sound knowledge of the principles of cerebral physiology and anesthetic neuropharmacology will facilitate the care of pediatric neurosurgical patients.

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Citations
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Impact of sevoflurane anesthesia on cerebral blood flow in children younger than 2 years.

TL;DR: To assess the impact of sevoflurane and anesthesia‐induced hypotension on cerebral blood flow (CBF) in children younger than 2 years, a large number of children were randomly assigned to the “good” or “bad” group.
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Impact of sevoflurane anesthesia on brain oxygenation in children younger than 2 years.

TL;DR: To assess the impact of sevoflurane and anesthesia‐induced hypotension on brain oxygenation in children younger than 2 years, a large number of patients were referred to the neonatal intensive care unit.
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Brain temperature: heat production, elimination and clinical relevance.

TL;DR: The fundamental physiological principles of brain heat production, distribution and elimination under normal conditions are explained and why hypothermia cannot yet be recommended routinely in the management of children affected with various neurological insults are discussed.
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Anesthetic considerations for the pediatric oncology patient--part 2: systems-based approach to anesthesia.

TL;DR: This review presents a systems‐based approach to the impact from both tumor and its treatment in children, followed by a discussion of the relevant anesthetic considerations.
Book ChapterDOI

Basics and dynamics of neonatal and pediatric pharmacology.

TL;DR: A basic understanding of the developmental dynamics in pediatric pharmacology is also essential to delineating the future directions and priority areas of pediatric drug research and development.
References
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Journal ArticleDOI

Compartmental analysis of compliance and outflow resistance of the cerebrospinal fluid system

TL;DR: The distribution of compliance and outflow resistance between cerebral and spinal compartments was measured in anesthetized, ventilated cats by analysis of the cerebrospinal fluid (CSF) pressure response to changes in CSF volume.
Journal ArticleDOI

Impaired autoregulation of cerebral blood flow in the distressed newborn infant

TL;DR: Cerebral blood flow was measured, using the 133Xe clearance technique, a few hours after birth in 19 infants with varying degrees of respiratory distress syndrome, showing a linear relationship that was identical in infants with asphyxia at birth and infants with RDS only.
Journal ArticleDOI

Inhibition of Adrenal Steroidogenesis by the Anesthetic Etomidate

TL;DR: Physicians should be aware that etomidate inhibits adrenal steroidogenesis, and they should consider treating selected patients with corticosteroids if etamidate is used.
Journal ArticleDOI

Effects of sevoflurane, propofol, and adjunct nitrous oxide on regional cerebral blood flow, oxygen consumption, and blood volume in humans

TL;DR: The effects of sevoflurane and propofol as sole anesthetics and in combination with N2O on regional cerebral blood flow, metabolic rate of oxygen (rCMRO2), and blood volume (rCBV) in the living human brain using positron emission tomography are quantified.