Journal ArticleDOI
Impact of anesthetic agents on cerebrovascular physiology in children.
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TLDR
The understanding of the effects of anesthetic agents on the physiology of cerebral vasculature in the pediatric population has significantly increased in the past decade allowing a more rationale decision making in anesthesia management.Abstract:
care to children with neurologic pathologies. The cerebral physiology is influenced by the developmental stage of the child. The understanding of the effects of anesthetic agents on the physiology of cerebral vasculature in the pediatric population has significantly increased in the past decade allowing a more rationale decision making in anesthesia management. Although no single anesthetic technique can be recommended, sound knowledge of the principles of cerebral physiology and anesthetic neuropharmacology will facilitate the care of pediatric neurosurgical patients.read more
Citations
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Propofol: a review of its role in pediatric anesthesia and sedation
TL;DR: There is no direct evidence in humans for propofol-induced neurotoxicity to the infant brain; however, current concerns of neuroapoptosis in developing brains induced by prop ofol persist and continue to be a focus of research.
Journal ArticleDOI
Near-infrared spectroscopy: exposing the dark (venous) side of the circulation.
John P. Scott,George M. Hoffman +1 more
TL;DR: Near‐infrared spectroscopy provides noninvasive continuous access to the venous side of regional circulations that can approximate organ‐specific and global measures to facilitate the detection of circulatory abnormalities and drive goal‐directed interventions to reduce end‐organ ischemic injury.
Journal ArticleDOI
Total intravenous anesthesia will supercede inhalational anesthesia in pediatric anesthetic practice
TL;DR: The advantages of total intravenous anesthesia (TIVA) have emerged and driven change in practice as mentioned in this paper, and these advantages will justify why TIVA will supercede inhalational anesthesia in future pediatric anesthetic practice.
Benzodiazepine receptors mediate regional bloodflowchanges in theliving humanbrain
TL;DR: In this paper, the effects of a high affinity gamma-aminobutyric acid (GABA)-benzodiazepine-receptor agonist (lorazepam) and an antagonist (flumazenil) in humans, using H2(15)O positron-emission tomography were studied.
References
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Journal ArticleDOI
Anesthetics and cerebral edema.
Allan L. Smith,Jeffrey J. Marque +1 more
TL;DR: The authors conclude that pentobarbital and fentanyl-droperidol (Innovar) limit the extent of cerebral edema, but that inhaled anesthetics do not.
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Effects of nitrous oxide on cerebral haemodynamics and metabolism during isoflurane anaesthesia in man
TL;DR: It is confirmed that N2O is a potent cerebral vasodilator in man, although the mechanisms underlying the effects on CBF are still unclear.
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A comparison of the direct cerebral vasodilating potencies of halothane and isoflurane in the New Zealand white rabbit
TL;DR: The results suggest that the relative effects of halothane and isoflurane on CBF are dependent on the CMR present prior to their administration, and when initial CMR is depressed, halothanes and is ofluranes have similar vasodilating potencies.
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Thresholds for hypoxic cerebral vasodilation in volunteers.
TL;DR: The results suggest that hypoxemic cerebral vasodilatation may be measured noninvasively and that in normal human volunteers, the threshold is at an SpO2 of 90%, which is greater than that previously reported.
Journal ArticleDOI
Nitrous oxide increases cerebral blood flow velocity during pharmacologically induced EEG silence in humans.
Basil F. Matta,Arthur M. Lam +1 more
TL;DR: In patients with propofol-induced isoelectric EEG, the increase seen in Vmca with the introduction of N2O is mainly due to cerebral stimulation and increase in cerebral metabolic rate.