Journal ArticleDOI
Impact of anesthetic agents on cerebrovascular physiology in children.
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The understanding of the effects of anesthetic agents on the physiology of cerebral vasculature in the pediatric population has significantly increased in the past decade allowing a more rationale decision making in anesthesia management.Abstract:
care to children with neurologic pathologies. The cerebral physiology is influenced by the developmental stage of the child. The understanding of the effects of anesthetic agents on the physiology of cerebral vasculature in the pediatric population has significantly increased in the past decade allowing a more rationale decision making in anesthesia management. Although no single anesthetic technique can be recommended, sound knowledge of the principles of cerebral physiology and anesthetic neuropharmacology will facilitate the care of pediatric neurosurgical patients.read more
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Propofol: a review of its role in pediatric anesthesia and sedation
TL;DR: There is no direct evidence in humans for propofol-induced neurotoxicity to the infant brain; however, current concerns of neuroapoptosis in developing brains induced by prop ofol persist and continue to be a focus of research.
Journal ArticleDOI
Near-infrared spectroscopy: exposing the dark (venous) side of the circulation.
John P. Scott,George M. Hoffman +1 more
TL;DR: Near‐infrared spectroscopy provides noninvasive continuous access to the venous side of regional circulations that can approximate organ‐specific and global measures to facilitate the detection of circulatory abnormalities and drive goal‐directed interventions to reduce end‐organ ischemic injury.
Journal ArticleDOI
Total intravenous anesthesia will supercede inhalational anesthesia in pediatric anesthetic practice
TL;DR: The advantages of total intravenous anesthesia (TIVA) have emerged and driven change in practice as mentioned in this paper, and these advantages will justify why TIVA will supercede inhalational anesthesia in future pediatric anesthetic practice.
Benzodiazepine receptors mediate regional bloodflowchanges in theliving humanbrain
TL;DR: In this paper, the effects of a high affinity gamma-aminobutyric acid (GABA)-benzodiazepine-receptor agonist (lorazepam) and an antagonist (flumazenil) in humans, using H2(15)O positron-emission tomography were studied.
References
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The effects of propofol or sevoflurane on the estimated cerebral perfusion pressure and zero flow pressure.
TL;DR: The effects of propofol or sevoflurane on the estimated cerebral perfusion pressure (eCPP) and ZFP in the cerebral circulation were investigated using transcranial Doppler ultrasonography.
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Nitrous oxide is a potent cerebrovasodilator in humans when added to isoflurane. A transcranial Doppler study
TL;DR: Nitrous oxide during neurosurgical procedures is almost always given in combination with either volatile or intravenous anesthetics, and the modifying influence of such interventions has been studied clinically and in experimental settings.
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Cerebrovascular carbon dioxide reactivity in children anaesthetized with sevoflurane
TL;DR: CCO2R is preserved in healthy children anaesthetized with 1.0 MAC sevoflurane and air in 30% oxygen delivered through an Ayre's T piece by intermittent positive-pressure ventilation, while maintaining ventilation variables constant.
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Propofol decreases cerebral blood flow velocity in anesthetized children.
TL;DR: This study shows that a higher rate of prop ofol infusion is associated with lower CBFV and MAP values in children, and propofol’s cerebral vasoconstrictive properties may be responsible for this finding.