Impact of I/D polymorphism of angiotensin-converting enzyme 1 (ACE1) gene on the severity of COVID-19 patients.
Sushma Verma,Mohammad Abbas,Shrikant Verma,Faizan Haider Khan,Syed Tasleem Raza,Zeba Siddiqi,Israr Ahmad,Farzana Mahdi +7 more
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TLDR
In this paper, the authors investigated the association of ACE1 I/D polymorphism with severity of Covid-19 and found that ACE1 ID genotype was significantly independently associated with high socio-economic COVID-19 patients (OR: 2.48, 95% CI: 1.331-4.609).About:
This article is published in Infection, Genetics and Evolution.The article was published on 2021-03-04 and is currently open access. It has received 54 citations till now. The article focuses on the topics: Angiotensin II & Lung injury.read more
Citations
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Journal ArticleDOI
Genetic polymorphisms of ACE1, ACE2, and TMPRSS2 associated with COVID‐19 severity: A systematic review with meta‐analysis
TL;DR: Genetic polymorphisms of ACE1 rs4646994 DD‐genotype, ACE2 rs2285666 GG‐ genotype, and TMPRSS2 rs12329760 CC‐genotypes and C‐allele may serve as predictive models of COVID‐19 severity.
Journal ArticleDOI
ACE I/D polymorphism in Czech first-wave SARS-CoV-2-positive survivors.
Jaroslav A. Hubacek,Ladislav Dušek,Ondrej Majek,Vaclav Adamek,Tereza Cervinkova,Dana Dlouha,Vera Adamkova +6 more
TL;DR: In this article, the frequency of ACE I/I homozygotes was significantly increased in COVID-19 patients compared with that in controls (26.2% vs. 21.2%; P = 0.002; OR [95% CI] = 1.78 [1.22-2.60]).
Journal ArticleDOI
Association of GSTM1 and GSTT1 gene polymorphisms with COVID-19 susceptibility and its outcome.
Mohammad Abbas,Sushma Verma,Shrikant Verma,Sahabjada Siddiqui,Faizan Haider Khan,Syed Tasleem Raza,Zeba Siddiqi,Ale Eba,Farzana Mahdi +8 more
Journal ArticleDOI
ACE and ACE2 Gene Variants Are Associated With Severe Outcomes of COVID-19 in Men
Laura E. Martínez-Gómez,Brígida Herrera-López,Carlos Martinez-Armenta,Silvestre Ortega-Peña,M C Camacho-Rea,Carlos Suarez-Ahedo,Paola Vázquez-Cárdenas,Gilberto Vargas-Alarcón,Gustavo Rojas-Velasco,José Manuel Fragoso,Patricia Vidal-Vázquez,Juan Pablo Ramírez-Hinojosa,Yunuen Rodríguez-Sánchez,David R Barrón-Díaz,Mariana Laura Moreno,Felipe de J. Martínez-Ruiz,Dulce M. Zayago-Angeles,Monica Maribel Mata-Miranda,Gustavo Jesus Vazquez-Zapien,Adriana Martinez-Cuazitl,Edith Barajas-Galicia,Ludwing Bustamante-Silva,Diana Zazueta-Arroyo,José Manuel Rodríguez-Pérez,Olivia Hernández-González,Roberto Coronado-Zarco,Vania Lucas-Tenorio,Rafael Franco-Cendejas,Luis Esaú López-Jácome,Rocío Carmen Vázquez-Juárez,Jonathan J. Magaña,Marlid Cruz-Ramos,Julio Granados,Susana Hernández-Doño,Diego Delgado-Saldivar,Luis Ramos-Tavera,Irma A. Coronado-Zarco,Gustavo E. Guajardo-Salinas,José Francisco Muñoz-Valle,Carlos Pineda,Gabriela Angélica Martínez-Nava,Alberto López-Reyes +41 more
TL;DR: It is suggested that the T allele of rs2285666 represents a risk factor for severe and critical outcomes of COVID-19, especially for men, regardless of age, hypertension, obesity, and type 2 diabetes.
Journal ArticleDOI
The Renin-Angiotensin System: A Key Role in SARS-CoV-2-Induced COVID-19.
George El-Arif,Antonella Farhat,Shaymaa Khazaal,Cédric Annweiler,Hervé Kovacic,Yingliang Wu,Zhijian Cao,Ziad Fajloun,Ziad Abi Khattar,Jean-Marc Sabatier +9 more
TL;DR: In this paper, the authors explored the correlation between host genetic polymorphisms (especially in the renin-angiotensin system) as well as other related factors such age, gender, lifestyle and habits and underlying pathologies or comorbidities that could render individuals at higher risk of infection and pathogenicity.
References
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Characteristics of and Important Lessons From the Coronavirus Disease 2019 (COVID-19) Outbreak in China: Summary of a Report of 72 314 Cases From the Chinese Center for Disease Control and Prevention
Zunyou Wu,Jennifer M. McGoogan +1 more
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An insertion/deletion polymorphism in the angiotensin I-converting enzyme gene accounting for half the variance of serum enzyme levels.
TL;DR: The insertion/deletion polymorphism accounted for 47% of the total phenotypic variance of serum ACE, showing that the ACE gene locus is the major locus that determines serum ACE concentration.
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Prevalence of comorbidities and its effects in patients infected with SARS-CoV-2: a systematic review and meta-analysis.
Jing Yang,Ya Zheng,Xi Gou,Ke Pu,Zhaofeng Chen,Qinghong Guo,Rui Ji,Haojia Wang,Yuping Wang,Yongning Zhou +9 more
TL;DR: The prevalence of comorbidities in infected patients and risk factors for severe compared with non-severe patients are assessed to help the health sector guide vulnerable populations and assess the risk of deterioration.
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Outbreak of pneumonia of unknown etiology in Wuhan, China: The mystery and the miracle.
TL;DR: A new-type coronav virus, tentatively named by World Health Organization as the 2019-new coronavirus (2019-nCoV), had caused this outbreak in Wuhan city, Hubei Province, China, it was announced today.
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