Journal ArticleDOI
Impact of polymorphisms of the major histocompatibility complex class II, interleukin-10, tumor necrosis factor-alpha and cytotoxic T-lymphocyte antigen-4 genes on inhibitor development in severe hemophilia A.
A. Pavlova,D. Delev,Sébastien Lacroix-Desmazes,Rainer Schwaab,M. Mende,Rolf Fimmers,Jan Astermark,Johannes Oldenburg +7 more
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TLDR
The higher frequencies of the −308G>A polymorphism in TNF‐α and −1082A>G in IL‐10 in inhibitor patients confirmed the earlier published data.About:
This article is published in Journal of Thrombosis and Haemostasis.The article was published on 2009-12-01. It has received 169 citations till now. The article focuses on the topics: Allele frequency & Human leukocyte antigen.read more
Citations
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Journal ArticleDOI
Factor VIII Products and Inhibitor Development in Severe Hemophilia A
Samantha C. Gouw,Johanna G. van der Bom,Rolf Ljung,Carmen Escuriola,Ana Rosa Cid,Ségolène Claeyssens-Donadel,Christel Van Geet,Gili Kenet,Anne Mäkipernaa,Angelo Claudio Molinari,Wolfgang Muntean,Rainer Kobelt,George E Rivard,E. Santagostino,Angela Thomas,H. Marijke van den Berg +15 more
TL;DR: Recombinant and plasma-derived factor VIII products conferred similar risks of inhibitor development, and the content of von Willebrand factor in the products and switching among products were not associated with the risk of inhibitors development.
Journal ArticleDOI
F8 gene mutation type and inhibitor development in patients with severe hemophilia A: systematic review and meta-analysis
Samantha C. Gouw,Samantha C. Gouw,H. Marijke van den Berg,Johannes Oldenburg,Jan Astermark,Philip G. de Groot,Maurizio Margaglione,Arthur R. Thompson,Waander L. van Heerde,Jorien Boekhorst,Connie H. Miller,Saskia le Cessie,Johanna G. van der Bom +12 more
TL;DR: The primary outcome was inhibitor development and the secondary outcome was high-titer-inhibitor development, and the relative risks for developing high titer inhibitors were similar.
Journal ArticleDOI
Modern haemophilia care.
Erik Berntorp,Amy D. Shapiro +1 more
TL;DR: Long-term substitution therapy of the missing clotting factor is the recommended treatment in severe haemophilia, but several research issues remain to be elucidated such as when to start and how to optimise these regimens, and when or whether to stop this expensive treatment.
Journal ArticleDOI
Intensity of factor VIII treatment and inhibitor development in children with severe hemophilia A: the RODIN study
Samantha C. Gouw,H. Marijke van den Berg,Krista Fischer,Guenter Auerswald,Manuel Carcao,Elizabeth Chalmers,Hervé Chambost,Karin Kurnik,Ri Liesner,Pia Petrini,Helen Platokouki,Carmen Altisent,Johannes Oldenburg,Beatrice Nolan,Rosario Perez Garrido,M Elisa Mancuso,Anne Rafowicz,Michael Williams,Niels Clausen,Rutger A. Middelburg,Rolf Ljung,Johanna G. van der Bom +21 more
TL;DR: It is suggested that in previously untreated patients with severe hemophilia A, high-dosed intensive FVIII treatment increases inhibitor risk and prophylactic FV III treatment decreases inhibitor risk, especially in patients with low-risk F8 mutations.
Journal ArticleDOI
Factor VIII inhibitors in hemophilia A: rationale and latest evidence.
Char Witmer,Guy Young +1 more
TL;DR: This review summarizes the current evidence regarding inhibitor risk factors, eradication, and hemostatic bypassing agents.
References
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Journal ArticleDOI
A Simple Sequentially Rejective Multiple Test Procedure
TL;DR: In this paper, a simple and widely accepted multiple test procedure of the sequentially rejective type is presented, i.e. hypotheses are rejected one at a time until no further rejections can be done.
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A simple salting out procedure for extracting DNA from human nucleated cells
TL;DR: A rapid, safe and inexpensive method was developed to simplify the deprotein-ization procedure that yielded quantities comparable to those obtained from phenol-chloroform extractions, rendering the entire process of RFLP analysis free of toxic materials.
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Effects of a polymorphism in the human tumor necrosis factor α promoter on transcriptional activation
TL;DR: It is demonstrated, with reporter genes under the control of the two allelic TNF promoters, that TNF2 is a much stronger transcriptional activator than the common allele (TNF1) in a human B cell line.
Journal ArticleDOI
An investigation of polymorphism in the interleukin-10 gene promoter.
TL;DR: Three single base pair substitutions in the IL-10 gene promoter are identified and it is investigated whether this polymorphism correlates withIL-10 protein production in vitro.
Journal ArticleDOI
Definitions in hemophilia. Recommendation of the scientific subcommittee on factor VIII and factor IX of the scientific and standardization committee of the International Society on Thrombosis and Haemostasis.
Gilbert C. White,Frits R. Rosendaal,Louis M. Aledort,Jeanne M. Lusher,Chantal Rothschild,Jørgen Ingerslev +5 more
TL;DR: Definitions in Hemophilia - Recommendation of the Scientific Subcommittee on Factor VIII and Factor IX and the Scientific and Standardization Committee of the International Society on Thrombosis and Haemostasis.